Depression is one of the most common comorbidities of many chronic medical diseases
including cancer and cardiovascular, metabolic, inflammatory and neurological disorders …

Background Many depressed patients are not able to achieve or sustain symptom remission
despite serial treatment trials–often termed “treatment resistant depression”. A broader …

Our understanding of chronic pain involves complex brain circuits that include sensory,
emotional, cognitive and interoceptive processing. The feed-forward interactions between …

A revision of the 2008 British Association for Psychopharmacology evidence-based
guidelines for treating depressive disorders with antidepressants was undertaken in order to …

The bidirectional relationship between depression and chronic pain is well-recognized, but
their clinical management remains challenging. Here we characterize the shared risk factors …

Background and aims Patients seeking care for a pain problem very often also report
symptoms of depression. In fact, depression is associated with the development of chronic …

Background: Symptoms of depression and anxiety commonly coexist with chronic
musculoskeletal pain, and when this occurs, standard orthopedic treatment is less effective …

Importance Among patients seeking care for musculoskeletal conditions, there is mixed
evidence regarding whether traditional, structure-based care is associated with …

Depression and smoking are common comorbid conditions among adults with chronic pain.
The aim of this study was to determine the independent effects of depression on clinical pain …

Patients with multiple somatic symptoms are common in primary care settings, in which more
than half of all visits are for somatic complaints. 1 For some of the most common symptoms …