BACKGROUND: The Pediatric Heart Network is conducting a large international
randomized trial to compare aortic root growth and other cardiovascular outcomes in 608 …

Background and purpose: Aortic complications account for the major mortality in Marfan
syndrome (MFS), a connective tissue disorder caused by mutations in FBN1 encoding …

Patients with Marfan syndrome (MFS) develop thoracic aortic aneurysms as the aorta
presents excessive elastin breaks, fibrosis, and vascular smooth muscle cell (vSMC) death …

Introduction The international recommendations tend to avoid physical activity (PA) for
patients with Marfan syndrome (MFS). However, exceptions have recently been made in the …

Marfan syndrome (MFS) is an autosomal-dominant disorder of connective tissue caused by
mutations in the fibrillin-1 (FBN1) gene. Mortality is often due to aortic dissection and rupture …

Background Aortic stiffness is an important marker of cardiovascular risk and is elevated in
children and adolescents with congenital heart disease (CHD) compared with healthy …

Abstract Background Patients with Marfan (MFS) and Loeys–Dietz (LDS) syndromes have
been shown to have abnormal aortic biophysical properties. The purpose of this study was …

The Pediatric Heart Network randomized trial of atenolol versus losartan in the Marfan
syndrome showed no treatment differences in the rates of aortic-root growth or clinical …

Background Aortic dilation, stiffening, and dissection are common and potentially lethal
complications of Marfan syndrome (MFS) and Loeys-Dietz syndrome (LDS), which involve …

OBJECTIVE: To assess the biophysical properties of the aorta in children born small for
gestational age (SGA) with an echo-Doppler method and to determine associations with …