Review of pharmacological options for the treatment of Chagas disease

F Lascano, F García Bournissen… - British journal of clinical …, 2022 - Wiley Online Library
Chagas disease (CD) is a worldwide problem, with over 8 million people infected in both
rural and urban areas. CD was first described over a century ago, but only two drugs are …

[HTML][HTML] Molecular and clinical aspects of chronic manifestations in Chagas disease: a state-of-the-art review

GJ Medina-Rincón, S Gallo-Bernal, PA Jiménez… - Pathogens, 2021 - mdpi.com
Chronic manifestations of Chagas disease present as disabling and life-threatening
conditions affecting mainly the cardiovascular and gastrointestinal systems. Although …

[HTML][HTML] Automatic detection of the parasite Trypanosoma cruzi in blood smears using a machine learning approach applied to mobile phone images

MCC Morais, D Silva, MM Milagre, MT de Oliveira… - PeerJ, 2022 - peerj.com
Chagas disease is a life-threatening illness caused by the parasite Trypanosoma cruzi. The
diagnosis of the acute form of the disease is performed by trained microscopists who detect …

Enfermedad de Chagas (tripanosomiasis americana)

G Murillo-Godínez - Medicina interna de México, 2018 - scielo.org.mx
La enfermedad de Chagas (tripanosomiasis americana) es una zoonosis descrita en Brasil,
en 1909, por Carlos Chagas. Afecta a cerca de 20 millones de personas distribuidas en …

[HTML][HTML] Chagas cardiomyopathy: from Romaña sign to heart failure and sudden cardiac death

A Pino-Marín, GJ Medina-Rincón, S Gallo-Bernal… - Pathogens, 2021 - mdpi.com
Despite nearly a century of research and accounting for the highest disease burden of any
parasitic disease in the Western Hemisphere, Chagas disease (CD) is still a challenging …

[HTML][HTML] Clinical and epidemiological characterization of acute Chagas disease in Casanare, Eastern Colombia, 2012–2020

CY Rincón-Acevedo, AS Parada-García… - Frontiers in …, 2021 - frontiersin.org
Background: Chagas disease (CD), caused by the protozoan Trypanosoma cruzi, is
considered a public health problem in Latin America. In Colombia, it affects more than …

Ross-Macdonald models: Which one should we use?

MI Simoy, JP Aparicio - Acta tropica, 2020 - Elsevier
Ross-Macdonald models are the building blocks of most vector-borne disease models. Even
for the same disease, different authors use different model formulations, but a study of the …

Drugs in preclinical and early clinical development for the treatment of Chagas´ s disease: the current status

FKVS Torchelsen, AL Mazzeti… - Expert Opinion on …, 2024 - Taylor & Francis
Introduction Chagas disease is spreading faster than expected in different countries, and
little progress has been reported in the discovery of new drugs to combat Trypanosoma cruzi …

[HTML][HTML] Oral Route Driven Acute Trypanosoma cruzi Infection Unravels an IL-6 Dependent Hemostatic Derangement

D Antunes, A Marins-Dos-Santos, MT Ramos… - Frontiers in …, 2019 - frontiersin.org
Oral transmission of Trypanosoma cruzi, the etiologic agent of Chagas disease, is presently
the most important route of infection in Brazilian Amazon. Other South American countries …

Trypanosoma cruzi blood trypomastigotes induce intense skeletal and cardiac muscle damage and Th1/Th2 immune response in the acute phase of mice infected by …

G Dehesa-Rodríguez, I Martínez, C Bastida-Jaime… - Acta Tropica, 2022 - Elsevier
Oral acquisition of Trypanosoma cruzi is a foodborne transmission by juices and fruits
contaminated with metacyclic trypomastigotes (MT) or by the ingestion of wild reservoirs …