Enhancing immunotherapy in cancer by targeting emerging immunomodulatory pathways
L Kraehenbuehl, CH Weng, S Eghbali… - Nature reviews Clinical …, 2022 - nature.com
The discovery and clinical implementation of immune-checkpoint inhibitors (ICIs) targeting
CTLA4, PD-1 and PD-L1 has revolutionized the treatment of cancer, as recognized by the …
CTLA4, PD-1 and PD-L1 has revolutionized the treatment of cancer, as recognized by the …
[HTML][HTML] Current strategies to enhance delivery of drugs across the blood–brain barrier
RI Teleanu, MD Preda, AG Niculescu, O Vladâcenco… - Pharmaceutics, 2022 - mdpi.com
The blood–brain barrier (BBB) has shown to be a significant obstacle to brain medication
delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from …
delivery. The BBB in a healthy brain is a diffusion barrier that prevents most substances from …
[PDF][PDF] Delineating the conformational landscape of the adenosine A2A receptor during G protein coupling
G-protein-coupled receptors (GPCRs) represent a ubiquitous membrane protein family and
are important drug targets. Their diverse signaling pathways are driven by complex …
are important drug targets. Their diverse signaling pathways are driven by complex …
[HTML][HTML] Cancer biology and molecular genetics of A3 adenosine receptor
C Mazziotta, JC Rotondo, C Lanzillotti, G Campione… - Oncogene, 2022 - nature.com
Abstract A3 adenosine receptor (A3AR) is a cell membrane protein, which has been found to
be overexpressed in a large number of cancer types. This receptor plays an important role in …
be overexpressed in a large number of cancer types. This receptor plays an important role in …
[HTML][HTML] A raising dawn of pentoxifylline in management of inflammatory disorders in Covid-19
G Mostafa-Hedeab, HM Al-Kuraishy, AI Al-Gareeb… - …, 2022 - Springer
The existing pandemic viral infection caused by severe acute respiratory syndrome
coronavirus type 2 (SARS-CoV-2) leads to coronavirus disease 2019 (Covid-19). SARS …
coronavirus type 2 (SARS-CoV-2) leads to coronavirus disease 2019 (Covid-19). SARS …
Allosteric modulation of the adenosine A2A receptor by cholesterol
SK Huang, O Almurad, RJ Pejana, ZA Morrison… - Elife, 2022 - elifesciences.org
Cholesterol is a major component of the cell membrane and commonly regulates membrane
protein function. Here, we investigate how cholesterol modulates the conformational …
protein function. Here, we investigate how cholesterol modulates the conformational …
[HTML][HTML] Modulation of the blood–brain barrier for drug delivery to brain
L Han - Pharmaceutics, 2021 - mdpi.com
The blood–brain barrier (BBB) precisely controls brain microenvironment and neural activity
by regulating substance transport into and out of the brain. However, it severely hinders drug …
by regulating substance transport into and out of the brain. However, it severely hinders drug …
[HTML][HTML] Adenosine and the cardiovascular system: the good and the bad
R Guieu, JC Deharo, B Maille, L Crotti… - Journal of clinical …, 2020 - mdpi.com
Adenosine is a nucleoside that impacts the cardiovascular system via the activation of its
membrane receptors, named A1R, A2AR, A2BR and A3R. Adenosine is released during …
membrane receptors, named A1R, A2AR, A2BR and A3R. Adenosine is released during …
[HTML][HTML] Emerging roles of dysregulated adenosine homeostasis in brain disorders with a specific focus on neurodegenerative diseases
CP Chang, KC Wu, CY Lin, Y Chern - Journal of Biomedical Science, 2021 - Springer
In modern societies, with an increase in the older population, age-related
neurodegenerative diseases have progressively become greater socioeconomic burdens …
neurodegenerative diseases have progressively become greater socioeconomic burdens …
[HTML][HTML] Receptors involved in mental disorders and the use of clozapine, chlorpromazine, olanzapine, and aripiprazole to treat mental disorders
Mental illnesses are a global health challenge, and effective medicines are needed to treat
these conditions. Psychotropic drugs are commonly prescribed to manage mental disorders …
these conditions. Psychotropic drugs are commonly prescribed to manage mental disorders …