Microtubules are core components of the eukaryotic cytoskeleton with essential roles in cell
division, shaping, motility and intracellular transport. Despite their functional heterogeneity …

Platelets—blood cells continuously produced from megakaryocytes mainly in the bone
marrow—are implicated not only in haemostasis and arterial thrombosis, but also in other …

Platelet size has been demonstrated to reflect platelet activity and seems to be a useful
predictive and prognostic biomarker of cardiovascular events. It is associated with a variety …

Rationale: Coronavirus disease 2019 (COVID-19) is characterized by increased incidence
of microthrombosis with hyperactive platelets sporadically containing viral RNA. It is unclear …

Rationale: In addition to the overwhelming lung inflammation that prevails in coronavirus
disease 2019 (COVID-19), hypercoagulation and thrombosis contribute to the lethality of …

The transcription factor NF-κB is a central mediator of inflammation with multiple links to
thrombotic processes. In this review, we focus on the role of NF-κB signaling in cell types …

Circulating tumor cells (CTCs) are the seeds of distant metastasis, and the number of CTCs
detected in the blood of cancer patients is associated with a worse prognosis. CTCs face …

Platelets are critical for haemostasis, thrombosis, and inflammatory responses,, but the
events that lead to mature platelet production remain incompletely understood. The bone …

Platelets are small anucleate cells present in the blood stream, their typical role in primary
hemostasis has been well-described. However, new evidence suggests that they have …

Upon activation, platelets secrete more than 300 active substances from their intracellular
granules. Platelet dense granule components, such as ADP and polyphosphates, contribute …