The skin, which is comprised of the epidermis, dermis, and subcutaneous tissue, is the
largest organ in the human body and it plays a crucial role in the regulation of the body's …

Stress is associated with the onset and severity of several psychiatric disorders that occur
more frequently in women than men, including posttraumatic stress disorder (PTSD) and …

The physiological stress response is responsible for the maintenance of homeostasis in the
presence of real or perceived challenges. In this function, the brain activates adaptive …

Psycho-neuro-endocrine-immune modulation through the brain-gut axis likely has a key role
in the pathogenesis of inflammatory bowel disease (IBD). The brain-gut axis involves …

Melatonin production is highly conserved in nature through different species including
bacteria, unicellular eukaryotes, algae, plants invertebrates, and vertebrates (Hardeland et …

Centralized pain syndromes are associated with changes within the central nervous system
that amplify peripheral input and/or generate the perception of pain in the absence of a …

The discovery of corticotropin-releasing factor (CRF) or CRH defining the upper regulatory
arm of the hypothalamic-pituitary-adrenal (HPA) axis, along with the identification of the …

Major depression, with its strikingly high prevalence, is the most common cause of disability
in communities of Western type, according to data of the World Health Organization. Stress …

Glucocorticoid synthesis is a complex, multistep process that starts with cholesterol being
delivered to the inner membrane of mitochondria by StAR and StAR-related proteins. Here …

Although the higher incidence of stress-related psychiatric disorders in females is well
documented, its basis is unknown. Here, we show that the receptor for corticotropin …