Dysregulation of mitochondrial homeostasis is common to all types of cardiovascular
diseases. SIRT3 regulates apoptosis and autophagy, material and energy metabolism …

Simple Summary Increasing number of cancer patients and significant mortality among
these patients are attributed to many factors including anticancer drug resistance. Among a …

Melatonin confers cardioprotective effects on multiple cardiovascular diseases, including
doxorubicin-induced cardiomyopathy. The effectiveness of melatonin in mitigating …

Although chemotherapy drugs are extensively utilized in cancer therapy, their administration
for treatment of patients has faced problems that regardless of chemoresistance, increasing …

Doxorubicin induced cardiotoxicity (DIC) arises from mitochondrial dysfunction and oxidative
stress. Oridonin (Ori), a natural tetracycline diterpenoid, has shown cardiac protective effect; …

Rosacea is a long-term inflammatory skin disease associated with the dysfunction of
vascular and immunological systems. Treatment options for rosacea are difficult to …

Background Doxorubicin (DOX) is a widely utilized anthracycline chemotherapy drug in
cancer treatment, yet its efficacy is hindered by both short-term and long-term cardiotoxicity …

Doxorubicin (DOX), an anthracycline-based chemotherapeutic agent, is widely used to treat
various types of cancer; however, prolonged treatment induces cardiomyotoxicity. Although …

In recent years, the emergence of cancer drug resistance is one of the crucial tumor
hallmarks which is supported by the level of genetic heterogeneity and complexities at …