Efficacy of a Pseudomonas aeruginosa serogroup O9 vaccine

DA Moustafa, A DiGiandomenico… - Infection and …, 2023 - Am Soc Microbiol
There are currently no approved vaccines against the opportunistic pathogen Pseudomonas
aeruginosa. Among vaccine targets, the lipopolysaccharide (LPS) O antigen of P …

[HTML][HTML] Concordance in pathogen identification at the upper and lower respiratory tract of children with severe pneumonia

H Wang, X Li, Y Zheng, LM Verhagen, J Gu, L Li… - BMC infectious …, 2023 - Springer
Background Nasopharyngeal swabs are taken to determine the causative agent of
community acquired pneumonia (CAP), while the reliability of upper respiratory tract …

[HTML][HTML] Immunization and Immunotherapy Approaches against Pseudomonas aeruginosa and Burkholderia cepacia Complex Infections

SA Sousa, AMM Seixas, JMM Marques, JH Leitão - Vaccines, 2021 - mdpi.com
Human infections caused by the opportunist pathogens Burkholderia cepacia complex and
Pseudomonas aeruginosa are of particular concern due to their severity, their multiple …

[HTML][HTML] Iron Acquisition Proteins of Pseudomonas aeruginosa as Potential Vaccine Targets: In Silico Analysis and In Vivo Evaluation of Protective Efficacy of the …

AS Hamad, EA Edward, E Sheta, HM Aboushleib… - Vaccines, 2022 - mdpi.com
Background: Pseudomonas aeruginosa (PA) is a Gram-negative pathogen responsible for
fatal nosocomial infections worldwide. Iron is essential for Gram-negative bacteria to …

[HTML][HTML] A Pseudomonas aeruginosa-Derived Particulate Vaccine Protects against P. aeruginosa Infection

ZJC Gonzaga, C Merakou, A DiGiandomenico… - Vaccines, 2021 - mdpi.com
Despite numerous efforts to develop an effective vaccine against P seudomonas
aeruginosa, no vaccine has yet been approved for human use. This study investigates the …

The SIRT3 activator ganoderic acid D regulates airway mucin MUC5AC expression via the NRF2/GPX4 pathway

J Wang, J Li, Y He, X Huang, J Feng, L Liu, Y Liu… - Pulmonary …, 2023 - Elsevier
Purpose The expression of MUC5AC, a highly prevalent airway mucin, is regulated by
stimulatory factors such as oxidative stress. Ganoderic acid D (GAD) activates mitochondrial …

Chemical Synthesis and Antigenicity Evaluation of an Aminoglycoside Trisaccharide Repeating Unit of Pseudomonas aeruginosa Serotype O5 O-Antigen Containing a Rare …

G Tian, J Hu, C Qin, L Li, Y Ning, S Zhu… - Journal of the …, 2024 - ACS Publications
Pseudomonas aeruginosa bacteria are becoming increasingly resistant against multiple
antibiotics. Therefore, the development of vaccines to prevent infections with these bacteria …

Histone acetyltransferases derived RW20 protects and promotes rapid clearance of Pseudomonas aeruginosa in zebrafish larvae

A Guru, R Murugan, J Arockiaraj - International Microbiology, 2024 - Springer
Pseudomonas is a group of bacteria that can cause a wide range of infections, particularly in
people with weakened immune systems, such as those with cystic fibrosis or who are …

Intranasal Delivery of Antigen-Coated Polymer Particles Protects against Pseudomonas aeruginosa Infection

ZJC Gonzaga, J Zhang, BHA Rehm - ACS Infectious Diseases, 2022 - ACS Publications
Pseudomonas aeruginosa is an opportunistic human pathogen that is intrinsically resistant
to multiple antibiotics, causing severe and persistent infections in immunocompromised …

[HTML][HTML] A unique antigen against SARS-CoV-2, Acinetobacter baumannii, and Pseudomonas aeruginosa

MR Rahbar, SMH Mubarak, A Hessami, B Khalesi… - Scientific Reports, 2022 - nature.com
The recent outbreak of COVID-19 has increased hospital admissions, which could elevate
the risk of nosocomial infections, such as A. baumannii and P. aeruginosa infections …