Memory B cells (MBCs) are long-lived and produce high-affinity, generally, class-switched
antibodies. Here, we use a multiparameter approach involving CD27 to segregate naïve B …

Systemic lupus erythematosus (SLE) is an autoimmune disorder that is characterized by
autoantibody production and dysregulated immune cell activation. Although the exact …

As a safe, feasible, and inexpensive dietary intervention, fasting-mimicking diet (FMD)
exhibits excellent antitumor efficacy by regulating metabolism and boosting antitumor …

Valproic acid (VPA) is widely recognized for its use in the control of epilepsy and other
neurological disorders in the past 50 years. Recent evidence has shown the potential of …

Epigenetics connects genetic and environmental factors: it includes DNA methylation,
histone post‐translational modifications and the regulation of chromatin accessibility by non …

Epigenetics refers to the study of mechanisms controlling the chromatin structure, which has
fundamental role in the regulation of gene expression and genome stability. Epigenetic …

The generation of memory is a cardinal feature of the adaptive immune response, involving
different factors in a complex process of cellular differentiation. This process is essential for …

Plasma cells provide high-affinity antibodies against invading pathogens. Although
transcriptional and epigenetic mechanisms have been extensively studied for plasma cell …

B cells play a pivotal role in the pathogenesis of autoimmune diseases. Although previous
studies have shown many genetic polymorphisms associated with B-cell activation in …

The number of people diagnosed with chronic inflammatory diseases has increased
noteworthy in the last 40 years. Spondyloarthritis (SpA), inflammatory bowel diseases (IBD) …