The increased susceptibility to infections of neonates is caused by an immaturity of the
immune system as a result of both qualitative and quantitative differences between neonatal …

Non-coding RNAs (ncRNAs) have diverse roles in the differentiation of hematopoietic cells.
Among these transcripts, long ncRNAs (lncRNAs) and microRNAs (miRNAs) have especial …

The epigenetic landscape undergoes a widespread modulation during embryonic
development and cell differentiation. Within the hematopoietic system, B cells are perhaps …

Objective Disease‐associated, differentially hypermethylated regions have been reported in
rheumatoid arthritis (RA), but no DNA methyltransferase inhibitors have been evaluated in …

Background MicroRNAs are important mediators of post-transcriptional regulation of gene
expression through RNA degradation and translational repression, and are emerging …

N6‐methyladenosine (m6A) modification plays a pivotal role in cell fate determination.
Previous studies show that eliminating m6A using Mb1-Cre dramatically impairs B cell …

As we have suggested, epigenetic factors, such as microRNAs (miRNAs), can interact with
genetic programs to regulate B cell functions, thereby informing antibody and autoantibody …

IgG autoantibodies mediate pathology in systemic lupus patients and lupus-prone mice. In
this study, we showed that the class-switched IgG autoantibody response in MRL/Fas lpr/lpr …

Estrogen contributes to females' strong antibody response to microbial vaccines and
proneness to autoimmunity, particularly antibody-mediated systemic autoimmunity, in …

Immunodeficiencies (IDs) are disorders of the immune system that increase susceptibility to
infections and cancer, and are therefore associated with elevated morbidity and mortality …