Highlights•B cell-intrinsic epigenetic mechanisms and factors regulate AID and Blimp-1
expression.•Tet2 actively demethylates Aicda super-enhancer elements to derepress Aicda …

Severe sepsis, septic shock, and related inflammatory syndromes are driven by the aberrant
expression of proinflammatory mediators by immune cells. During the acute phase of sepsis …

A better understanding of stable changes in regulation of gene expression that result from
epigenetic events is of great relevance in the development of strategies to prevent and treat …

Enhancer and super-enhancers are master regulators of cell fate. While they act at long-
distances on adjacent genes, it is unclear whether they also act on one another. The …

The ribozyme-sensitive element NHE-III1 in the P1 promoter region of the important proto-
oncogene c-myc contains many guanine (G)-rich sequences. Induction and stabilization of …

Background: Maternal exposure to dietary factors during pregnancy may modulate the
immunity of offspring by epigenetic programming. But the relationship between intrauterine …

Background Deposition of immune complexes drives podocyte injury acting in the initial
phase of lupus nephritis (LN), a process mediated by B cell involvement. Accordingly …

In B cells, Ig class switch recombination (CSR) is initiated by activation-induced cytidine
deaminase (AID), the activity of which leads to DNA double-strand breaks (DSBs) within IgH …

B cell differentiation is associated with substantial transcriptional, metabolic, and epigenetic
remodeling, including redistribution of histone 3 lysine 27 trimethylation (H3K27me3), which …

Background Previous studies have shown that γδ TFH cells are capable of modulating
antibody production in immunized and infected mouse model. In recent studies, human γδ …