Epigenetic modifications are the heritable changes in gene expression patterns that are
independent of primary DNA sequence changes and affect the expression of a locus or …

Immunosuppressive drug therapy is required to treat patients with autoimmune disease and
patients who have undergone organ transplantation. The main targets of the …

Background SLE is likely triggered by gene–environment interactions. We have shown that
most SLE-associated haplotypes encompass genomic regions enriched for epigenetic …

In the twenty-first century emergence, the rapid spread and pathogenicity associated with
SARS-CoV-2 have put a tremendous impact on the human population leading to the …

B cell differentiation into Ab-secreting plasma cells requires transcriptional, metabolic, and
epigenetic remodeling. Histone H3 lysine 27 trimethylation (H3K27me3), a histone …

Heterochromatin loss and genetic instability enhance cancer progression by favoring clonal
diversity, yet uncontrolled replicative stress can lead to mitotic catastrophe and inflammatory …

Highlights•B cell development requires coordinated, sequential changes in epigenome
landscapes.•3-D nuclear re-organization is essential for B cell differentiation.•LncRNAs are …

Epigenetics refers to heritable phenotype changes that do not involve alterations in the DNA
sequence. While DNA methylation and histone modifications represent the classical …

The production of high-affinity and broadly neutralizing antibodies plays a key role in the
defense against pathogens. These antibody responses require effective germinal center …

Canine distemper (CD) is a significant threat to wild and captive giant panda populations.
Captive giant pandas are inoculated with canine distemper virus (CDV) vaccination to …