Single-cell RNA sequencing (scRNA-seq) allows researchers to collect large catalogues
detailing the transcriptomes of individual cells. Unsupervised clustering is of central …

Cancer metastasis is no longer viewed as a linear cascade of events but rather as a series
of concurrent, partially overlapping processes, as successfully metastasizing cells assume …

The intestinal epithelium is a highly structured tissue composed of repeating crypt-villus
units. Enterocytes perform the diverse tasks of absorbing a wide range of nutrients while …

Malignant cell growth is fueled by interactions between tumor cells and the stromal cells
composing the tumor microenvironment. The human liver is a major site of tumors and …

Cancer is the quintessential complex disease. As technologies evolve faster each day, we
are able to quantify the different layers of biological elements that contribute to the …

The explosive growth of artificial intelligence (AI) technologies, especially deep learning
methods, has been translated at revolutionary speed to efforts in AI-assisted healthcare …

Single‐cell transcriptomics provides us with completely new insights into the molecular
diversity of different cell types and the different states they can adopt. The technique …

Multiplex single-molecule fluorescent in situ hybridization (smFISH) is a powerful method for
validating RNA sequencing and emerging spatial transcriptomic data, but quantification …

Spatial heterogeneity is a fundamental feature of the tumor microenvironment (TME), and
tackling spatial heterogeneity in neoplastic metabolic aberrations is critical for tumor …

Immunotherapy is a rapidly growing field for cancer treatment. In contrast to conventional
cancer therapies, immunotherapeutic strategies focus on reactivating the immune system to …