Type 2 immunity in the skin and lungs

CA Akdis, PD Arkwright, MC Brüggen, W Busse… - Allergy, 2020 - Wiley Online Library
There has been extensive progress in understanding the cellular and molecular
mechanisms of inflammation and immune regulation in allergic diseases of the skin and …

Mast cell biology at molecular level: a comprehensive review

D Elieh Ali Komi, S Wöhrl, L Bielory - Clinical reviews in allergy & …, 2020 - Springer
Mast cells (MCs) are portions of the innate and adaptive immune system derived from bone
marrow (BM) progenitors that are rich in cytoplasmic granules. MC maturation, phenotype …

Mast cells in the skin: defenders of integrity or offenders in inflammation?

M Voss, J Kotrba, E Gaffal… - International Journal of …, 2021 - mdpi.com
Mast cells (MCs) are best-known as key effector cells of immediate-type allergic reactions
that may even culminate in life-threatening anaphylactic shock syndromes. However …

[HTML][HTML] Mast cells as protectors of health

A Dudeck, M Köberle, O Goldmann, N Meyer… - Journal of Allergy and …, 2019 - Elsevier
Mast cells (MCs), which are well known for their effector functions in TH 2-skewed allergic
and also autoimmune inflammation, have become increasingly acknowledged for their role …

Amplification of snake venom toxicity by endogenous signaling pathways

PE Bickler - Toxins, 2020 - mdpi.com
The active components of snake venoms encompass a complex and variable mixture of
proteins that produce a diverse, but largely stereotypical, range of pharmacologic effects and …

The evolution of IgE‐mediated type I hypersensitivity and its immunological value

DI Pritchard, FH Falcone, PD Mitchell - Allergy, 2021 - Wiley Online Library
The allergic phenotype manifests itself in a spectrum of troublesome to life‐threatening
diseases, from seasonal hay fever, through the food allergies, atopic eczema, asthma, to …

Immunological responses to envenomation

RYM Ryan, J Seymour, A Loukas, JA Lopez… - Frontiers in …, 2021 - frontiersin.org
Venoms are complex mixtures of toxic compounds delivered by bite or sting. In humans, the
consequences of envenomation range from self-limiting to lethal. Critical host defence …

Mast Cell Activation Syndrome Update—A Dermatological Perspective

DM Mihele, PA Nistor, G Bruma, CI Mitran… - Journal of Personalized …, 2023 - mdpi.com
Mast cells (MCs) are infamous for their role in potentially fatal anaphylaxis reactions. In the
last two decades, a more complex picture has emerged, as it has become obvious that MCs …

The functional biology of peanut allergens and possible links to their allergenicity

P Ozias‐Akins, H Breiteneder - Allergy, 2019 - Wiley Online Library
Peanut is one of the most common food triggers of fatal anaphylaxis worldwide although
peanut allergy affects only 1%‐2% of the general population. Peanuts are the source of …

Killer immunoglobulin-like receptor 2DL4 (Cd158d) regulates human mast cells both positively and negatively: Possible roles in pregnancy and cancer metastasis

TR Kataoka, C Ueshima, M Hirata… - International journal of …, 2020 - mdpi.com
Killer immunoglobulin-like receptor (KIR) 2DL4 (CD158d) was previously thought to be a
human NK cell-specific protein. Mast cells are involved in allergic reactions via their KIT …