Bridging smart nanosystems with clinically relevant models and advanced imaging for precision drug delivery
Q Zhou, Q Liu, Y Wang, J Chen, O Schmid… - Advanced …, 2024 - Wiley Online Library
Intracellular delivery of nano‐drug‐carriers (NDC) to specific cells, diseased regions, or
solid tumors has entered the era of precision medicine that requires systematic knowledge …
solid tumors has entered the era of precision medicine that requires systematic knowledge …
Electrotransfer for nucleic acid and protein delivery
A Muralidharan, PE Boukany - Trends in Biotechnology, 2023 - cell.com
Electrotransfer of nucleic acids and proteins has become crucial in biotechnology for gene
augmentation and genome editing. This review explores the applications of electrotransfer …
augmentation and genome editing. This review explores the applications of electrotransfer …
Breaking genetic shackles: The advance of base editing in genetic disorder treatment
F Xu, C Zheng, W Xu, S Zhang, S Liu… - Frontiers in …, 2024 - frontiersin.org
The rapid evolution of gene editing technology has markedly improved the outlook for
treating genetic diseases. Base editing, recognized as an exceptionally precise genetic …
treating genetic diseases. Base editing, recognized as an exceptionally precise genetic …
Advanced micro/nano-electroporation for gene therapy: recent advances and future outlook
F Liu, R Su, S Wang, W Mu, L Chang - Nanoscale, 2024 - pubs.rsc.org
Gene therapy is a promising disease treatment approach by editing target genes, and thus
plays a fundamental role in precision medicine. To ensure gene therapy efficacy, the …
plays a fundamental role in precision medicine. To ensure gene therapy efficacy, the …
Transdermal gene delivery
W Zhang, Y Jiao, Z Zhang, Y Zhang, J Yu… - Journal of Controlled …, 2024 - Elsevier
Gene delivery has revolutionized conventional medical approaches to vaccination, cancer,
and autoimmune diseases. However, current gene delivery methods are limited to either …
and autoimmune diseases. However, current gene delivery methods are limited to either …
Non-viral delivery of RNA for therapeutic T cell engineering
D Berdecka, SC De Smedt, WH De Vos… - Advanced Drug Delivery …, 2024 - Elsevier
Adoptive T cell transfer has shown great success in treating blood cancers, resulting in a
growing number of FDA-approved therapies using chimeric antigen receptor (CAR) …
growing number of FDA-approved therapies using chimeric antigen receptor (CAR) …
A quantitative electrodiffusion model of antibacterial heavy metals: Ion influx through hydrophilic pores
JX Ma, MX Huang - Chemical Engineering Journal, 2024 - Elsevier
Excessive heavy-metal ions in the cytoplasm, being toxic ions, can inactivate bacteria, which
has been widely used as an effective antibacterial method. Nevertheless, how such toxic …
has been widely used as an effective antibacterial method. Nevertheless, how such toxic …
Probability and kinetics of rupture and electrofusion in giant unilamellar vesicles under various frequencies of direct current pulses
Irreversible electroporation induces permanent permeabilization of lipid membranes of
vesicles, resulting in vesicle rupture upon the application of a pulsed electric field …
vesicles, resulting in vesicle rupture upon the application of a pulsed electric field …
Therapeutic perspectives of high pulse repetition rate electroporation
A de Caro, F Talmont, MP Rols, M Golzio… - …, 2023 - Elsevier
Electroporation, a technique that uses electrical pulses to temporarily or permanently
destabilize cell membranes, is increasingly used in cancer treatment, gene therapy, and …
destabilize cell membranes, is increasingly used in cancer treatment, gene therapy, and …
Tolerability of a piezoelectric microneedle electroporator in human subjects
Electroporation, or the use of electric pulses to facilitate the intracellular delivery of DNA,
RNA, and other molecules, is a well‐established technique, that has been demonstrated to …
RNA, and other molecules, is a well‐established technique, that has been demonstrated to …