Bridging smart nanosystems with clinically relevant models and advanced imaging for precision drug delivery

Q Zhou, Q Liu, Y Wang, J Chen, O Schmid… - Advanced …, 2024 - Wiley Online Library
Intracellular delivery of nano‐drug‐carriers (NDC) to specific cells, diseased regions, or
solid tumors has entered the era of precision medicine that requires systematic knowledge …

Electrotransfer for nucleic acid and protein delivery

A Muralidharan, PE Boukany - Trends in Biotechnology, 2023 - cell.com
Electrotransfer of nucleic acids and proteins has become crucial in biotechnology for gene
augmentation and genome editing. This review explores the applications of electrotransfer …

Breaking genetic shackles: The advance of base editing in genetic disorder treatment

F Xu, C Zheng, W Xu, S Zhang, S Liu… - Frontiers in …, 2024 - frontiersin.org
The rapid evolution of gene editing technology has markedly improved the outlook for
treating genetic diseases. Base editing, recognized as an exceptionally precise genetic …

Advanced micro/nano-electroporation for gene therapy: recent advances and future outlook

F Liu, R Su, S Wang, W Mu, L Chang - Nanoscale, 2024 - pubs.rsc.org
Gene therapy is a promising disease treatment approach by editing target genes, and thus
plays a fundamental role in precision medicine. To ensure gene therapy efficacy, the …

Transdermal gene delivery

W Zhang, Y Jiao, Z Zhang, Y Zhang, J Yu… - Journal of Controlled …, 2024 - Elsevier
Gene delivery has revolutionized conventional medical approaches to vaccination, cancer,
and autoimmune diseases. However, current gene delivery methods are limited to either …

Non-viral delivery of RNA for therapeutic T cell engineering

D Berdecka, SC De Smedt, WH De Vos… - Advanced Drug Delivery …, 2024 - Elsevier
Adoptive T cell transfer has shown great success in treating blood cancers, resulting in a
growing number of FDA-approved therapies using chimeric antigen receptor (CAR) …

A quantitative electrodiffusion model of antibacterial heavy metals: Ion influx through hydrophilic pores

JX Ma, MX Huang - Chemical Engineering Journal, 2024 - Elsevier
Excessive heavy-metal ions in the cytoplasm, being toxic ions, can inactivate bacteria, which
has been widely used as an effective antibacterial method. Nevertheless, how such toxic …

Probability and kinetics of rupture and electrofusion in giant unilamellar vesicles under various frequencies of direct current pulses

MTI Bhuiyan, MAS Karal, US Orchi, N Ahmed… - Plos one, 2024 - journals.plos.org
Irreversible electroporation induces permanent permeabilization of lipid membranes of
vesicles, resulting in vesicle rupture upon the application of a pulsed electric field …

Therapeutic perspectives of high pulse repetition rate electroporation

A de Caro, F Talmont, MP Rols, M Golzio… - …, 2023 - Elsevier
Electroporation, a technique that uses electrical pulses to temporarily or permanently
destabilize cell membranes, is increasingly used in cancer treatment, gene therapy, and …

Tolerability of a piezoelectric microneedle electroporator in human subjects

CY Lu, P Rohilla, EI Felner… - Bioengineering & …, 2024 - Wiley Online Library
Electroporation, or the use of electric pulses to facilitate the intracellular delivery of DNA,
RNA, and other molecules, is a well‐established technique, that has been demonstrated to …