Polyamines are polycations that interact with negatively charged molecules such as DNA,
RNA and proteins. They play multiple roles in cell growth, survival and proliferation …

Polyamines are essential for the growth and function of normal cells. They interact with
various macromolecules, both electrostatically and covalently and, as a consequence, have …

There is shortage of extensive clinicopathologic studies of cellular senescence because the
most reliable senescence biomarker, the detection of Senescence-Associated-beta …

The polyamines spermidine and spermine and their diamine precursor putrescine are
naturally occurring, polycationic alkylamines that are essential for eukaryotic cell growth …

Cell senescence is broadly defined as the physiological program of terminal growth arrest,
which can be triggered by alterations of telomeres or by different forms of stress. Neoplastic …

p21Waf1/Cip1/Sdi1 is best known as a broad-specificity inhibitor of cyclin/cyclin-dependent
kinase complexes, but p21 also interacts with many other regulators of transcription or signal …

Polyamines are aliphatic cations present in all cells. In normal cells, polyamine levels are
intricately controlled by biosynthetic and catabolic enzymes. The biosynthetic enzymes are …

Enhanced polyamine catabolism via polyamine acetylation-oxidation elevates the oxidative
stress in an organism due to increased production of reactive oxygen species (ROS). We …

The polyamines are ubiquitous polycationic compounds. Over the past 40 yr, investigation
has shown that some of these, namely spermine, spermidine, and putrescine, are essential …

The cellular polyamines putrescine, spermidine, and spermine are ubiquitous in nature and
have been implicated in a wide range of growth and developmental processes. There is little …