The immunobiology of preterm labor and birth: intra-amniotic inflammation or breakdown of maternal–fetal homeostasis
In brief The syndrome of preterm labor comprises multiple established and novel etiologies.
This review summarizes the distinct immune mechanisms implicated in preterm labor and …
This review summarizes the distinct immune mechanisms implicated in preterm labor and …
Inflammasomes: their role in normal and complicated pregnancies
Inflammasomes are cytoplasmic multiprotein complexes that coordinate inflammatory
responses, including those that take place during pregnancy. Inflammasomes and their …
responses, including those that take place during pregnancy. Inflammasomes and their …
Does the human placenta delivered at term have a microbiota? Results of cultivation, quantitative real-time PCR, 16S rRNA gene sequencing, and metagenomics
Background The human placenta has been traditionally viewed as sterile, and microbial
invasion of this organ has been associated with adverse pregnancy outcomes. Yet, recent …
invasion of this organ has been associated with adverse pregnancy outcomes. Yet, recent …
Effector and activated T cells induce preterm labor and birth that is prevented by treatment with progesterone
M Arenas-Hernandez, R Romero, Y Xu… - The Journal of …, 2019 - journals.aai.org
Preterm labor commonly precedes preterm birth, the leading cause of perinatal morbidity
and mortality worldwide. Most research has focused on establishing a causal link between …
and mortality worldwide. Most research has focused on establishing a causal link between …
Intra-amniotic inflammation induces preterm birth by activating the NLRP3 inflammasome
J Faro, R Romero, G Schwenkel… - Biology of …, 2019 - academic.oup.com
Intra-amniotic inflammation is strongly associated with spontaneous preterm labor and birth,
the leading cause of perinatal mortality and morbidity worldwide. Previous studies have …
the leading cause of perinatal mortality and morbidity worldwide. Previous studies have …
[HTML][HTML] Fetal and maternal NLRP3 signaling is required for preterm labor and birth
Preterm birth is the leading cause of neonatal morbidity and mortality worldwide. One of
every 4 preterm neonates is born to a mother with intra-amniotic inflammation driven by …
every 4 preterm neonates is born to a mother with intra-amniotic inflammation driven by …
Inhibition of the NLRP3 inflammasome can prevent sterile intra-amniotic inflammation, preterm labor/birth, and adverse neonatal outcomes
N Gomez-Lopez, R Romero… - Biology of …, 2019 - academic.oup.com
Sterile intra-amniotic inflammation is commonly observed in patients with spontaneous
preterm labor, a syndrome that commonly precedes preterm birth, the leading cause of …
preterm labor, a syndrome that commonly precedes preterm birth, the leading cause of …
Innate lymphoid cells in the maternal and fetal compartments
Pregnancy success is orchestrated by the complex balance between the maternal and fetal
immune systems. Herein, we summarize the potential role of innate lymphoid cells (ILCs) in …
immune systems. Herein, we summarize the potential role of innate lymphoid cells (ILCs) in …
[HTML][HTML] Clinical chorioamnionitis at term X: microbiology, clinical signs, placental pathology, and neonatal bacteremia–implications for clinical care
Objectives Clinical chorioamnionitis at term is considered the most common infection-related
diagnosis in labor and delivery units worldwide. The syndrome affects 5–12% of all term …
diagnosis in labor and delivery units worldwide. The syndrome affects 5–12% of all term …
Inflammasomes—a molecular link for altered immunoregulation and inflammation mediated vascular dysfunction in preeclampsia
P Murthi, AA Pinar, E Dimitriadis… - International journal of …, 2020 - mdpi.com
Preeclampsia (PE) is a pregnancy-specific multisystem disorder and is associated with
maladaptation of the maternal cardiovascular system and abnormal placentation. One of the …
maladaptation of the maternal cardiovascular system and abnormal placentation. One of the …