Despite the recent increase in the development of antivirals and antibiotics, antimicrobial
resistance and the lack of broad-spectrum virus-targeting drugs are still important issues and …

Globally, human immunodeficiency virus type 1 (HIV-1) infection is a major health burden for
which successful therapeutic options are still being investigated. Challenges facing current …

Drug repurposing provides a rapid approach to meet the urgent need for therapeutics to
address COVID-19. To identify therapeutic targets relevant to COVID-19, we conducted …

Affinity-based biosensing can enable point-of-care diagnostics and continuous health
monitoring, which commonly follows bottom-up approaches and is inherently constrained by …

Psychiatric disorders impose tremendous economic burden on society and are leading
causes of disability worldwide. However, only limited drugs are available for psychiatric …

Ex vivo CRISPR gene editing in haematopoietic stem and progenitor cells has opened
potential treatment modalities for numerous diseases. The current process uses …

CCR5, a chemokine receptor central for orchestrating lymphocyte/cell migration to the sites
of inflammation and to the immunosurveillance, is involved in the pathogenesis of a wide …

The recalcitrance of pathogens to traditional antibiotics has made treating and eradicating
bacterial infections more difficult. In this regard, developing new antimicrobial agents to …

Antiretroviral therapy (ART) effectively reduces cycles of viral replication but does not target
proviral populations in cells that persist for prolonged periods and that can undergo clonal …

Terminal and benign diseases alike in adults, children, pregnant women, and others are
successfully treated by pharmacological inhibitors that target human enzymes. Despite …