Lysosomes are ubiquitous membrane-bound intracellular organelles with an acidic interior.
They are central for degradation and recycling of macromolecules delivered by endocytosis …

Autophagy, a vital catabolic process that degrades cytoplasmic components within the
lysosome, is an essential cytoprotective response to pathologic stresses that occur during …

Ageing leads to a functional deterioration of many brain systems, including the circadian
clock—an internal time-keeping system that generates∼ 24-hour rhythms in physiology and …

The ubiquitin-like molecule ATG12 is required for the early steps of autophagy. Recently, we
identified ATG3, the E2-like enzyme required for LC3 lipidation during autophagy, as an …

Glycosylation is one of the most common, and the most complex, forms of post‐translational
modification of proteins. This review serves to highlight the role of protein glycosylation in …

Autophagy is a vesicle and lysosome-mediated degradative pathway that is essential for
protein homeostasis and cell health. In particular, compared to nonneuronal cells, neurons …

1. INTRODUCTION In his 1959 keynote lecture “There is plenty of room at the bottom”,
Richard Feynman introduced the concepts that would later form the basis of a new era of …

Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disorder caused by
selective motor neuron degeneration. Abnormal protein aggregation and impaired protein …

Nanomaterials (NMs) are increasingly used for the therapy, diagnosis, and monitoring of
disease-or drug-induced mechanisms in the human biological system. In view of their small …

Since the identification of cyclin-dependent kinase-5 (Cdk5) as a tau kinase and member of
the Cdk family almost 20 years ago, deregulation of Cdk5 activity has been linked to an …