Role of Uropathogenic Escherichia coli Virulence Factors in Development of Urinary Tract Infection and Kidney Damage

J Bien, O Sokolova, P Bozko - International journal of …, 2012 - Wiley Online Library
Uropathogenic Escherichia coli (UPEC) is a causative agent in the vast majority of urinary
tract infections (UTIs), including cystitis and pyelonephritis, and infectious complications …

Intracellular Lifestyles and Immune Evasion Strategies of Uropathogenic Escherichia coli

DA Hunstad, SS Justice - Annual review of microbiology, 2010 - annualreviews.org
Paradigms in the pathogenesis of urinary tract infections have shifted dramatically as a
result of recent scientific revelations. Beyond extracellular colonization of the bladder …

The UPEC pore-forming toxin α-hemolysin triggers proteolysis of host proteins to disrupt cell adhesion, inflammatory, and survival pathways

BK Dhakal, MA Mulvey - Cell host & microbe, 2012 - cell.com
Uropathogenic Escherichia coli (UPEC), which are the leading cause of both acute and
chronic urinary tract infections, often secrete a labile pore-forming toxin known as α …

Anti-Adhesive Activity of Cranberry Phenolic Compounds and Their Microbial-Derived Metabolites against Uropathogenic Escherichia coli in Bladder Epithelial Cell …

DG de Llano, A Esteban-Fernández… - International journal of …, 2015 - mdpi.com
Cranberry consumption has shown prophylactic effects against urinary tract infections (UTI),
although the mechanisms involved are not completely understood. In this paper, cranberry …

[HTML][HTML] Interleukin-6/Stat3 signaling has an essential role in the host antimicrobial response to urinary tract infection

CB Ching, S Gupta, B Li, H Cortado, N Mayne… - Kidney international, 2018 - Elsevier
The signaling networks regulating antimicrobial activity during urinary tract infection (UTI)
are incompletely understood. Interleukin-6 (IL-6) levels increase with UTI severity, but the …

Some new findings regarding the antiadhesive activity of cranberry phenolic compounds and their microbial-derived metabolites against uropathogenic bacteria

D Gonzalez de Llano, H Liu, C Khoo… - Journal of agricultural …, 2019 - ACS Publications
Findings concerning the antiadhesive activity of cranberry phenolic compounds and their
microbial-derived metabolites against Gram-negative (Escherichia coli ATCC 53503 and …

Biofilm Formation and Immunomodulatory Activity of Proteus mirabilis Clinically Isolated Strains

A Fusco, L Coretti, V Savio, E Buommino… - International journal of …, 2017 - mdpi.com
Urinary tract infections (UTIs) and catheter-associated UTIs (CAUTIs) are the principal
hospital-acquired infections. Proteus mirabilis is characterized by several virulence factors …

Cytotoxic necrotizing factor 1 and hemolysin from uropathogenic Escherichia coli elicit different host responses in the murine bladder

TA Garcia, CL Ventura, MA Smith, DS Merrell… - Infection and …, 2013 - Am Soc Microbiol
ABSTRACT Cytotoxic necrotizing factor 1 (CNF1) and hemolysin (HlyA1) are toxins
produced by uropathogenic Escherichia coli (UPEC). We previously showed that these …

Molecular Basis of Uropathogenic Escherichia coli Evasion of the Innate Immune Response in the Bladder

BK Billips, AJ Schaeffer, DJ Klumpp - Infection and immunity, 2008 - Am Soc Microbiol
In the urinary tract, the innate immune system detects conserved bacterial components and
responds to infection by activating the proinflammatory transcription factor NF-κB, resulting …

Subversion of Host Innate Immunity by Uropathogenic Escherichia coli

PD Olson, DA Hunstad - Pathogens, 2016 - mdpi.com
Uropathogenic Escherichia coli (UPEC) cause the majority of community-onset urinary tract
infections (UTI) and represent a major etiologic agent of healthcare-associated UTI …