Cancer cell plasticity during tumor progression, metastasis and response to therapy
A Pérez-González, K Bévant, C Blanpain - Nature cancer, 2023 - nature.com
Cell plasticity represents the ability of cells to be reprogrammed and to change their fate and
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …
identity, enabling homeostasis restoration and tissue regeneration following damage. Cell …
Therapy resistance: opportunities created by adaptive responses to targeted therapies in cancer
Normal cells explore multiple states to survive stresses encountered during development
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …
and self-renewal as well as environmental stresses such as starvation, DNA damage, toxins …
Diverse clonal fates emerge upon drug treatment of homogeneous cancer cells
Even among genetically identical cancer cells, resistance to therapy frequently emerges
from a small subset of those cells,,,,,–. Molecular differences in rare individual cells in the …
from a small subset of those cells,,,,,–. Molecular differences in rare individual cells in the …
Cancer evolution: Darwin and beyond
Clinical and laboratory studies over recent decades have established branched evolution as
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …
a feature of cancer. However, while grounded in somatic selection, several lines of evidence …
The journey from melanocytes to melanoma
PP Centeno, V Pavet, R Marais - Nature Reviews Cancer, 2023 - nature.com
Over the past decade, melanoma has led the field in new cancer treatments, with impressive
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …
gains in on-treatment survival but more modest improvements in overall survival. Melanoma …
Towards precision oncology with patient-derived xenografts
ER Zanella, E Grassi, L Trusolino - Nature Reviews Clinical Oncology, 2022 - nature.com
Under the selective pressure of therapy, tumours dynamically evolve multiple adaptive
mechanisms that make static interrogation of genomic alterations insufficient to guide …
mechanisms that make static interrogation of genomic alterations insufficient to guide …
Drug-tolerant persister cells in cancer: the cutting edges and future directions
Y Pu, L Li, H Peng, L Liu, D Heymann… - Nature Reviews …, 2023 - nature.com
Drug-tolerant persister (DTP) cell populations were originally discovered in antibiotic-
resistant bacterial biofilms. Similar populations with comparable features have since been …
resistant bacterial biofilms. Similar populations with comparable features have since been …
Chromosomal instability accelerates the evolution of resistance to anti-cancer therapies
Aneuploidy is a ubiquitous feature of human tumors, but the acquisition of aneuploidy
typically antagonizes cellular fitness. To investigate how aneuploidy could contribute to …
typically antagonizes cellular fitness. To investigate how aneuploidy could contribute to …
Acquired resistance to KRAS G12C small-molecule inhibitors via genetic/nongenetic mechanisms in lung cancer
Inherent or acquired resistance to sotorasib poses a substantialt challenge for NSCLC
treatment. Here, we demonstrate that acquired resistance to sotorasib in isogenic cells …
treatment. Here, we demonstrate that acquired resistance to sotorasib in isogenic cells …
Single cell multi-omics reveal intra-cell-line heterogeneity across human cancer cell lines
Q Zhu, X Zhao, Y Zhang, Y Li, S Liu, J Han… - Nature …, 2023 - nature.com
Human cancer cell lines have long served as tools for cancer research and drug discovery,
but the presence and the source of intra-cell-line heterogeneity remain elusive. Here, we …
but the presence and the source of intra-cell-line heterogeneity remain elusive. Here, we …