The role of genetics, epigenetics, and the environment in ASD: A mini review

AA Khogeer, IS AboMansour, DA Mohammed - Epigenomes, 2022 - mdpi.com
According to recent findings, variances in autism spectrum disorder (ASD) risk factors might
be determined by several factors, including molecular genetic variants. Accumulated …

Convergent canonical pathways in autism spectrum disorder from proteomic, transcriptomic and DNA methylation data

C Mahony, C O'Ryan - International journal of molecular sciences, 2021 - mdpi.com
Autism Spectrum Disorder (ASD) is a complex neurodevelopmental disorder with extensive
genetic and aetiological heterogeneity. While the underlying molecular mechanisms …

Genetic relationships between attention-deficit/hyperactivity disorder, autism spectrum disorder, and intelligence

S Rao, A Baranova, Y Yao, J Wang, F Zhang - Neuropsychobiology, 2022 - karger.com
Introduction: Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder
(ASD) commonly co-occur; both traits exert an influence on intelligence scores. Genetic …

Shared genetics between autism spectrum disorder and attention-deficit/hyperactivity disorder and their association with extraversion

A Baranova, J Wang, H Cao, JH Chen, J Chen… - Psychiatry …, 2022 - Elsevier
Background Deciphering the genetic relationships between autism spectrum disorder (ASD)
and attention-deficit/hyperactivity disorder (ADHD) may uncover underlining shared …

Genomic architecture of autism spectrum disorder in Qatar: The BARAKA-Qatar Study

M Abdi, E Aliyev, B Trost, M Kohailan, W Aamer… - Genome Medicine, 2023 - Springer
Background Autism spectrum disorder (ASD) is a neurodevelopmental condition
characterized by impaired social and communication skills, restricted interests, and …

Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith–Magenis syndrome

YT Chang, M Kowalczyk… - Proceedings of the …, 2022 - National Acad Sciences
Hyperexcitability of brain circuits is a common feature of autism spectrum disorders (ASDs).
Genetic deletion of a chromatin-binding protein, retinoic acid induced 1 (RAI1), causes …

Investigating behavioral phenotypes related to autism spectrum disorder in a gene-environment interaction model of Cntnap2 deficiency and Poly I:C maternal …

FL Haddad, C De Oliveira, S Schmid - Frontiers in Neuroscience, 2023 - frontiersin.org
Introduction Autism Spectrum Disorder (ASD) has been associated with a wide variety of
genetic and environmental risk factors in both human and preclinical studies. Together …

Early postnatal development of the MDGA2+/-mouse model of synaptic dysfunction

E Fertan, AA Wong, TS Garvock-de Montbrun… - Behavioural Brain …, 2023 - Elsevier
Synaptic dysfunction underlies many neurodevelopmental disorders (NDDs). The
membrane-associated mucin domain-containing glycosylphosphatidylinositol anchor …

Gray matter covariations in autism: out-of-sample replication using the ENIGMA autism cohort

T Mei, A Llera, NJ Forde, D van Rooij, DL Floris… - Molecular Autism, 2024 - Springer
Background Autism spectrum disorder (henceforth autism) is a complex
neurodevelopmental condition associated with differences in gray matter (GM) volume …

Influence of gestational chlorpyrifos exposure on ASD-like behaviors in an fmr1-KO rat model

C Perez-Fernandez, M Matamala Montoya… - Molecular …, 2022 - Springer
Based on previous reports, exposure to pesticides could be linked to the prevalence
increase of autism spectrum disorders (ASD). Gestational exposure to chlorpyrifos (CPF) …