A structural scaffold embedding brain cells and vasculature is known as extracellular matrix
(ECM). The physical appearance of ECM in the central nervous system (CNS) ranges from a …

The perineuronal net (PNN) is a highly latticed extracellular matrix in the central nervous
system, which is composed of hyaluronic acid, proteoglycan, hyaluronan and proteoglycan …

Stroke is the second leading cause of death worldwide and has two major subtypes:
ischemic stroke and hemorrhagic stroke. Neuroinflammation is a pathological hallmark of …

It has long been found that hyaluronidases exist in a variety of organisms, playing their roles
in various biological processes including infection, envenomation and metabolic regulation …

Chondroitin sulfate (CS) is the most abundant and widely distributed glycosaminoglycan
(GAG) in the human body. As a component of proteoglycans (PGs) it has numerous roles in …

In the last decade, hyaluronic acid (HA) has attracted an ever-growing interest in the
biomedical engineering field as a biocompatible, biodegradable, and chemically versatile …

Medical adhesives are advanced but challenging alternatives to wound closure and repair,
especially in mitigating uncontrolled hemorrhage. Ideal hemostatic adhesives need to meet …

CD44 is a transmembrane protein that transduces extracellular stimuli to immune response.
Neuroinflammation is a causative factor in neurodegenerative diseases, such as Parkinson's …

Although the literature about the functions of hyaluronan and the CD44 receptor in the brain
and brain tumours is extensive, the role of the receptor for hyaluronan-mediated motility …

This review examines the roles of HS–proteoglycans (HS–PGs) in general, and, in
particular, perlecan and syndecan as representative examples and their interactive ligands …