[HTML][HTML] Epigenetic regulation of aging: implications for interventions of aging and diseases
K Wang, H Liu, Q Hu, L Wang, J Liu, Z Zheng… - Signal transduction and …, 2022 - nature.com
Aging is accompanied by the decline of organismal functions and a series of prominent
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
hallmarks, including genetic and epigenetic alterations. These aging-associated epigenetic …
[HTML][HTML] The landscape of aging
Aging is characterized by a progressive deterioration of physiological integrity, leading to
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
impaired functional ability and ultimately increased susceptibility to death. It is a major risk …
Making sense of the ageing methylome
Over time, the human DNA methylation landscape accrues substantial damage, which has
been associated with a broad range of age-related diseases, including cardiovascular …
been associated with a broad range of age-related diseases, including cardiovascular …
[HTML][HTML] Immunosenescence: molecular mechanisms and diseases
Z Liu, Q Liang, Y Ren, C Guo, X Ge, L Wang… - Signal transduction and …, 2023 - nature.com
Infection susceptibility, poor vaccination efficacy, age-related disease onset, and neoplasms
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …
are linked to innate and adaptive immune dysfunction that accompanies aging (known as …
[HTML][HTML] Therapeutic application of quercetin in aging-related diseases: SIRT1 as a potential mechanism
Z Cui, X Zhao, FK Amevor, X Du, Y Wang, D Li… - Frontiers in …, 2022 - frontiersin.org
Quercetin, a naturally non-toxic flavonoid within the safe dose range with antioxidant, anti-
apoptotic and anti-inflammatory properties, plays an important role in the treatment of aging …
apoptotic and anti-inflammatory properties, plays an important role in the treatment of aging …
DNA damage and repair in age-related inflammation
Genomic instability is an important driver of ageing. The accumulation of DNA damage is
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …
believed to contribute to ageing by inducing cell death, senescence and tissue dysfunction …
Relationships among smoking, oxidative stress, inflammation, macromolecular damage, and cancer
Smoking is a major risk factor for a variety of diseases, including cancer and immune-
mediated inflammatory diseases. Tobacco smoke contains a mixture of chemicals, including …
mediated inflammatory diseases. Tobacco smoke contains a mixture of chemicals, including …
In vivo partial reprogramming alters age-associated molecular changes during physiological aging in mice
Partial reprogramming by expression of reprogramming factors (Oct4, Sox2, Klf4 and c-Myc)
for short periods of time restores a youthful epigenetic signature to aging cells and extends …
for short periods of time restores a youthful epigenetic signature to aging cells and extends …
Long-term maturation of human cortical organoids matches key early postnatal transitions
Human stem-cell-derived models provide the promise of accelerating our understanding of
brain disorders, but not knowing whether they possess the ability to mature beyond mid-to …
brain disorders, but not knowing whether they possess the ability to mature beyond mid-to …
Inflammatory memory and tissue adaptation in sickness and in health
S Naik, E Fuchs - Nature, 2022 - nature.com
Our body has a remarkable ability to remember its past encounters with allergens,
pathogens, wounds and irritants, and to react more quickly to the next experience. This …
pathogens, wounds and irritants, and to react more quickly to the next experience. This …