More than half a century ago, zinc was established as an essential micronutrient for normal
human physiology. In silico data suggest that about 10% of the human proteome potentially …

The transcription factors Oct4, Sox2, Klf4, and c-Myc enable the reprogramming of somatic
cells into induced pluripotent cells. Reprogramming generates newly differentiated cells for …

As healthspan and lifespan research breakthroughs have become more commonplace, the
need for valid, practical markers of biological age is becoming increasingly paramount. The …

Aging is a natural physiological process, but one that poses major challenges in an
increasingly aging society prone to greater health risks such as diabetes, cardiovascular …

The impact of healthy aging on molecular programming of immune cells is poorly
understood. Here we report comprehensive characterization of healthy aging in human …

Young blood plasma is known to confer beneficial effects on various organs in mice.
However, it was not known whether young plasma rejuvenates cells and tissues at the …

Abstract N6-methyladenosine (m6A) in mRNA and 5-methylcytosine (5mC) in DNA have
critical functions for regulating gene expression and modulating plant growth and …

Aging and obesity are high risk factors for several conditions and diseases. They are both
associated with systemic inflammation and they are both ameliorated by a healthy life style …

Abstract N6‐methyladenosine (m6A) is a dynamic and reversible RNA modification that has
emerged as a crucial player in the life cycle of RNA, thus playing a pivotal role in various …

Background Intact expression of podocyte histone deacetylases (HDAC) during
development is essential for maintaining a normal glomerular filtration barrier because of its …