Ubiquitination is an essential regulator of most, if not all, signalling pathways, and defects in
cellular signalling are central to cancer initiation, progression and, eventually, metastasis …

The epidermal growth factor receptor (EGFR) triggers the activation of many intracellular
signals that control cell proliferation, growth, survival, migration, and differentiation. Given its …

Transcriptional deregulation is a hallmark of many cancers and is exemplified by genomic
amplifications of the MYC family of oncogenes, which occur in at least 20% of all solid …

The chemical synthesis of site‐specifically modified transcription factors (TFs) is a powerful
method to investigate how post‐translational modifications (PTMs) influence TF‐DNA …

Myc is a powerful transcription factor implicated in epigenetic reprogramming, cellular
plasticity, and rapid growth as well as tumorigenesis. Cancer in skeletal muscle is extremely …

In pancreatic ductal adenocarcinoma (PDAC), endogenous MYC is required for S-phase
progression and escape from immune surveillance. Here we show that MYC in PDAC cells …

How the KRAS oncogene drives cancer growth remains poorly understood. Therefore, we
established a systemwide portrait of KRAS-and extracellular signal–regulated kinase (ERK) …

Simple Summary The cell division cycle is tightly regulated to ensure faithful and complete
DNA replication. A critical cell cycle phase is G1 in which cells prepare DNA for replication in …

Gamete (sperm and oocyte) genomes are transcriptionally silent until embryonic genome
activation (EGA) following fertilization. EGA in humans had been thought to occur around the …

MYC, a key member of the Myc-proto-oncogene family, is a universal transcription amplifier
that regulates almost every physiological process in a cell including cell cycle, proliferation …