Diastole is the sequence of physiological events that occur in the heart during ventricular
filling and principally depends on myocardial relaxation and chamber stiffness. Abnormal …

Background The associations of homocysteine (Hcy) and gene-Hcy interactions with the risk
of all-cause and cause-specific mortality remain unclear. Methods A total of 19,826 middle …

Inflammatory and infectious upper respiratory diseases (ICD-10: J30-J39), such as diseases
of the sinonasal tract, pharynx and larynx, are growing health problems yet their genomic …

Genome-wide association studies (GWAS) have successfully identified associations for
cervical cancer, but the underlying mechanisms of cervical biology and pathology remain …

Atopic dermatitis (AD) is a common inflammatory skin condition and prior genome-wide
association studies (GWAS) have identified 71 associated loci. In the current study we …

Genome-wide association studies (GWAS) have identified thousands of disease-associated
non-coding variants, posing urgent needs for functional interpretation. Molecular …

GWAS involve testing genetic variants across the genomes of many individuals to identify
genotype-phenotype associations. GWAS have enabled the identification of numerous …

Genome-wide association studies (GWASs) have identified thousands of non-coding
variants that are associated with human complex traits and diseases. The analysis of such …

Otosclerosis is one of the most common causes of conductive hearing loss, affecting 0.3% of
the population. It typically presents in adulthood and half of the patients have a positive …

Pathogen-driven selection shaped adaptive mutations in immunity genes, including those
contributing to inflammatory disorders. Functional characterization of such adaptive variants …