Cannabis use disorder (CUD) remains a significant public health issue globally, affecting up
to one in five adults who use cannabis. Despite extensive research into the molecular …

Background Asthma is a heterogeneous common respiratory disease that remains poorly
understood. The established genetic associations fail to explain the high estimated …

Background Multiple sclerosis (MS) is a chronic inflammatory disease of the central nervous
system with a well-established genetic contribution to susceptibility. Over 200 genetic …

Lack of diversity and proportionate representation in genomics datasets and databases
contributes to inequity in healthcare outcomes globally. The relationships of human diversity …

Lichen planus (LP) is a T-cell-mediated inflammatory disease affecting squamous epithelia
in many parts of the body, most often the skin and oral mucosa. Cutaneous LP is usually …

Genome-wide association studies (GWASs) have uncovered numerous trait-associated loci
across the human genome, most of which are located in noncoding regions, making …

Tourette's disorder (TD) is a highly heritable childhood-onset neurodevelopmental disorder
and is caused by a complex interplay of multiple genetic and environmental factors. Yet, the …

Multiple sclerosis (MS) is an autoimmune disease of the central nervous system (CNS) that
results in significant neurodegeneration in the majority of those affected and is a common …

We conducted a genome-wide association study (GWAS) analysis of diverticular disease
(DivD) of intestine within 724,372 individuals and identified 150 independent genome-wide …

Aging is a major risk factor for cardiovascular and neurodegenerative disorders, with
considerable societal and economic implications. Healthy aging is accompanied by …