▪ Abstract We describe the formation, maturation, elimination, maintenance, and
regeneration of vertebrate neuromuscular junctions (NMJs), the best studied of all synapses …

The peripheral nervous system retains a considerable capacity for regeneration. However,
functional recovery rarely returns to the preinjury level no matter how accurate the nerve …

Sox proteins are characterized by possession of a DNA-binding domain with similarity to the
high-mobility group domain of the sex determining factor SRY. Here, we report on Sox10, a …

Neuronal activity influences myelination of the brain, but the molecular mechanisms
involved are largely unknown. Here, we report that oligodendrocyte progenitor cells (OPCs) …

The genesis of vertebrate peripheral ganglia poses the problem of how multipotent neural
crest stem cells (NCSCs) can sequentially generate neurons and then glia in a local …

Schwann cell phenotype is classified as either myelinating or nonmyelinating. Additional
phenotypic specialization is suggested, however, by the preferential reinnervation of muscle …

By imposing saltatory conduction on the nervous impulse, the principal role of the myelin
sheath is to allow the faster propagation of action potentials along the axons which it …

Schwann cells are a regenerative cell type. Following nerve injury, a differentiated
myelinating Schwann cell can dedifferentiate and regain the potential to proliferate. These …

Neural crest stem cells (NCSCs) persist in peripheral nerves throughout late gestation but
their function is unknown. Current models of nerve development only consider the …

Although knowledge of the functions of neurotrophins has advanced rapidly in recent years,
studies concerning the involvement of neurotrophins in glial–neuronal interactions rarely …