Autophagy has emerged as a critical lysosomal pathway that maintains cell function and
survival through the degradation of cellular components such as organelles and proteins …

The retina resides in an environment that is primed for the generation of reactive oxygen
species (ROS) and resultant oxidative damage. The retina is one of the highest oxygen …

Autophagy is a homeostatic process involved in the bulk degradation of cytoplasmic
components, including damaged organelles and proteins. In both genetic and dietary …

Cerebral ischemia-reperfusion (IR) is a complex pathological process. Although autophagy
can be evoked by ischemia, its involvement in the reperfusion phase after ischemia and its …

Macroautophagy is a multistep, vacuolar, degradation pathway terminating in the lysosomal
compartment, and it is of fundamental importance in tissue homeostasis. In this review, we …

Ischemia–reperfusion is a major component of injury in vascular occlusion both during liver
surgery and during liver transplantation. The pathophysiology of hepatic ischemia …

Liver ischemia/reperfusion (IR) injury is typified by an inflammatory response.
Understanding the cellular and molecular events underpinning this inflammation is …

Autophagy, or cellular self-digestion, is a cellular pathway crucial for development,
differentiation, survival, and homeostasis. Its implication in human diseases has been …

Beclin1 (Atg6) is a well-known key regulator of autophagy. Although Beclin1 is enzymatically
inert, it governs the autophagic process by regulating PtdIns3KC3-dependent generation of …

Hepatic steatosis, the first step in the progression of nonalcoholic fatty liver disease, is
characterized by triglyceride accumulation in hepatocytes and is highly prevalent in people …