The CRISPR/Cas9 system is an RNA-based adaptive immune system in bacteria and
archaea. Various studies have shown that it is possible to target a wide range of human …

Urokinase-type plasminogen activator receptor (uPAR or CD87) is a glycosyl-phosphatidyl-
inositol anchored (GPI) membrane protein. The uPAR primary ligand is the serine protease …

Gastric cancer (GC) is the most common gastrointestinal malignant tumor, and distant
metastasis is a critical factor in the prognosis of patients with GC. Understanding the …

Fibrotic diseases, such as systemic sclerosis (SSc), idiopathic pulmonary fibrosis, renal
fibrosis and liver cirrhosis are characterized by tissue overgrowth due to excessive …

Simple Summary The uPA/uPAR system is highly involved in cancer progression and
metastasis. Many studies have definitively assessed that the high expression of urokinase …

Tumorigenesis is closely related to the loss of control of many genes. Urokinase-type
plasminogen activator receptor (uPAR), a glycolipid-anchored protein on the cell surface, is …

In the context of precision medicine, disease treatment requires individualized strategies
based on the underlying molecular characteristics to overcome therapeutic challenges …

Simple Summary Discovered more than three decades ago, the urokinase-type
plasminogen activator receptor (uPAR) has now firmly established itself as a versatile …

Since the proposition of the pro‐invasive activity of proteolytic enzymes over 70 years ago,
several roles for proteases in cancer progression have been established. About half of the …

The diffuse-type gastric cancer (DGC) is a subtype of gastric cancer (GC) associated with
low HER2 positivity rate and insensitivity to chemotherapy and immune checkpoint …