Ninety percent of clinical drug development fails despite implementation of many successful
strategies, which raised the question whether certain aspects in target validation and drug …

The primary female sex hormones, estrogens, are responsible for the control of functions of
the female reproductive system, as well as the development of secondary sexual …

Increasing evidence points to biological sex as an important factor in the development and
phenotypical expression of Parkinson's disease (PD). Risk of developing PD is twice as high …

Nuclear receptors are classically defined as ligand-activated transcription factors that
regulate key functions in reproduction, development, and physiology. Humans have 48 …

Osteoporosis is one of the major bone disorders that affects both women and men, and
causes bone deterioration and bone strength. Bone remodeling maintains bone mass and …

Immune checkpoint blockade (ICB) therapies have significantly prolonged patient survival
across multiple tumor types, particularly in melanoma. Interestingly, sex-specific differences …

Phenolic compounds are minor metabolites usually present in mushroom species. Because
of their potential advantages for human health, such as antioxidant and other biological …

Estrogen governs the regulations of various pathological and physiological actions
throughout the body in both males and females. Generally, 17β-estradiol an endogenous …

The ongoing coronavirus disease 2019 (COVID-19) pandemic caused by the novel severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) necessitates strategies to identify …

The NR superfamily comprises 48 transcription factors in humans that control a plethora of
gene network programs involved in a wide range of physiologic processes. This review will …