Cancer is defined by the presence of uncontrollable cell growth, whereby improper
proliferative signaling has overcome regulation by cellular mechanisms. Transcription …

Bazedoxifene (BZA), a third‐generation selective estrogen receptor modulator (SERM), has
been combined with conjugated equine estrogen (CE) to create a tissue selective estrogen …

A flavonoid fraction of Herba Epimedii, including eight flavonoid glycoside compounds,
epimedoside A, ikarisoside F, baohuoside II, sagittatoside A, sagittatoside B, 7-O-rhamnosyl …

Cardiovascular disease (CVD) is the biggest cause of sickness and mortality worldwide in
both males and females. Clinical statistics demonstrate clear sex differences in risk …

Dysregulation of cholesterol homeostasis is associated with many diseases such as
cardiovascular disease and cancer. Liver X receptors (LXRs) are major upstream regulators …

Endocrine therapy is an effective option for the treatment of estrogen receptor alpha (ERα)-
positive breast cancers. Unfortunately, a large fraction of women relapse with endocrine …

Duchenne muscular dystrophy (DMD) is a progressive genetic myopathy that leads to heart
failure from dilated cardiomyopathy by early adulthood. Recent evidence suggests that …

OBJECTIVE The relationship between patient and meningioma characteristics and hormone
receptors (HRs) of progesterone, estrogen, and androgen remains poorly defined despite …

Background The rarity of systemic sclerosis (SSc) has hampered the development of
therapies for this intractable autoimmune disease. Induced pluripotent stem cell (iPSC) can …

The current therapeutic approach for the treatment of hormone dependent breast cancer
includes interference with estrogen receptors via either selective modulators or estrogens …