Fatty acid metabolism is known to support tumorigenesis and disease progression as well
as treatment resistance through enhanced lipid synthesis, storage and catabolism. More …

Oncogenic activation of the phosphatidylinositol-3-kinase (PI3K), protein kinase B
(PKB/AKT), and mammalian target of rapamycin (mTOR) pathway is a frequent event in …

Traditionally, peroxisome proliferator-activated receptor γ coactivator 1α (PGC-1α), a 91 kDa
transcription factor, regulates lipid metabolism and long-chain fatty acid oxidation by …

Background Metformin is widely used in the treatment of diabetes, and there is interest in
'repurposing'the drug for cancer prevention or treatment. However, the mechanism …

Resistance of cancer cells to chemotherapy is the first cause of cancer-associated death.
Thus, new strategies to deal with the evasion of drug response and to improve clinical …

Prostate cancer is the most common non-cutaneous cancer in men in the United States.
Cancer metabolism has emerged as a contemporary topic of great interest for improved …

Reprogramming of cellular metabolism is a hallmark of cancers. Cancer cells more readily
use glycolysis, an inefficient metabolic pathway for energy metabolism, even when sufficient …

Prostate cancer is the most frequent nonskin cancer and second most common cause of
cancer-related deaths in man. Prostate cancer is a clinically heterogeneous disease with …

Cellular transformation and cancer progression is accompanied by changes in the metabolic
landscape. Master co-regulators of metabolism orchestrate the modulation of multiple …

PGC1α is a transcription factor coactivator that influences a majority of cellular metabolic
pathways. Abnormal expression of PGC1α is associated with several chronic diseases and …