[HTML][HTML] Tropomyosin receptor kinase (TRK) biology and the role of NTRK gene fusions in cancer
The tropomyosin receptor kinase (TRK) family of receptor tyrosine kinases are encoded by
NTRK genes and have a role in the development and normal functioning of the nervous …
NTRK genes and have a role in the development and normal functioning of the nervous …
CREB family transcription factors are major mediators of BDNF transcriptional autoregulation in cortical neurons
BDNF signaling via its transmembrane receptor TrkB has an important role in neuronal
survival, differentiation, and synaptic plasticity. Remarkably, BDNF is capable of modulating …
survival, differentiation, and synaptic plasticity. Remarkably, BDNF is capable of modulating …
[HTML][HTML] A brain-centric model of suicidal behavior
The suicide death toll is alarmingly high, outnumbering deaths from war and homicide
worldwide (1). Many factors contribute to suicide death, making it difficult to prevent because …
worldwide (1). Many factors contribute to suicide death, making it difficult to prevent because …
[HTML][HTML] The association between migraine and physical exercise
FM Amin, S Aristeidou, C Baraldi… - The journal of headache …, 2018 - Springer
Background There is an unmet need of pharmacological and non-pharmacological
treatment options for migraine patients. Exercise can be used in the treatment of several …
treatment options for migraine patients. Exercise can be used in the treatment of several …
[HTML][HTML] Targeting neurotrophins to specific populations of neurons: NGF, BDNF, and NT-3 and their relevance for treatment of spinal cord injury
KM Keefe, IS Sheikh, GM Smith - International journal of molecular …, 2017 - mdpi.com
Neurotrophins are a family of proteins that regulate neuronal survival, synaptic function, and
neurotransmitter release, and elicit the plasticity and growth of axons within the adult central …
neurotransmitter release, and elicit the plasticity and growth of axons within the adult central …
[HTML][HTML] Core transcription programs controlling injury-induced neurodegeneration of retinal ganglion cells
Regulatory programs governing neuronal death and axon regeneration in
neurodegenerative diseases remain poorly understood. In adult mice, optic nerve crush …
neurodegenerative diseases remain poorly understood. In adult mice, optic nerve crush …
[HTML][HTML] Brain-derived neurotrophic factor: a bridge between inflammation and neuroplasticity
F Calabrese, AC Rossetti, G Racagni… - Frontiers in cellular …, 2014 - frontiersin.org
Cytokines are key regulatory mediators involved in the host response to immunological
challenges, but also play a critical role in the communication between the immune and the …
challenges, but also play a critical role in the communication between the immune and the …
[HTML][HTML] The effect of exercise training on resting concentrations of peripheral brain-derived neurotrophic factor (BDNF): a meta-analysis
Background The mechanisms through which physical activity supports healthy brain function
remain to be elucidated. One hypothesis suggests that increased brain-derived neurotrophic …
remain to be elucidated. One hypothesis suggests that increased brain-derived neurotrophic …
[HTML][HTML] The biology and pathobiology of glutamatergic, cholinergic, and dopaminergic signaling in the aging brain
A Gasiorowska, M Wydrych, P Drapich… - Frontiers in aging …, 2021 - frontiersin.org
The elderly population is growing worldwide, with important health and socioeconomic
implications. Clinical and experimental studies on aging have uncovered numerous …
implications. Clinical and experimental studies on aging have uncovered numerous …
Exercise mimetics: harnessing the therapeutic effects of physical activity
Exercise mimetics are a proposed class of therapeutics that specifically mimic or enhance
the therapeutic effects of exercise. Increased physical activity has demonstrated positive …
the therapeutic effects of exercise. Increased physical activity has demonstrated positive …