Major depressive disorder (MDD) has until recently been conceptualized as an episodic
disorder associated with 'chemical imbalances' but no permanent brain changes. Evidence …

Nerve growth factor (NGF) was discovered in the early 1950s due to its trophic (survival-and
growth-promoting) effects on sensory and sympathetic neurons (Levi-Montalcini and …

Accumulating evidence from animal and human studies supports the notion that physical
exercise can enhance neuroplasticity and thus reduce the risk of several neurodegenerative …

The ageing of the human brain is a cause of cognitive decline in the elderly and the major
risk factor for Alzheimer's disease. The time in life when brain ageing begins is undefined …

Surgical repair of severe peripheral nerve injuries represents not only a pressing medical
need, but also a great clinical challenge. Autologous nerve grafting remains a golden …

Nanotechnology is a field of research that has been stressed as a very valuable approach
for the prevention and treatment of different human health disorders. This has been stressed …

Major depressive disorder (MDD) affects millions of people worldwide and is a leading
cause of disability. Several theories have been proposed to explain its pathological …

Ketamine exerts fast acting, robust, and lasting antidepressant effects in a sub-anesthetic
dose, however, the underlying mechanisms are still not fully elucidated. Recent studies have …

Despite the ongoing fundamental controversy about the physiological function of sleep,
there is general consensus that sleep benefits neuronal plasticity, which ultimately supports …

▪ Abstract Neuronal circuits are shaped by experience during critical periods of early
postnatal life. The ability to control the timing, duration, and closure of these heightened …