The nuclear pore is the gatekeeper of nucleocytoplasmic transport and signaling through
which a vast flux of information is continuously exchanged between the nuclear and …

Hexanucleotide repeat expansions of variable size in C9orf72 are the most prevalent
genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia. Sense and …

An intronic hexanucleotide (GGGGCC) expansion in the C9orf72 gene is the most common
genetic cause of frontotemporal dementia (FTD) and amyotrophic lateral sclerosis (ALS). In …

The aberrant expansion of GGGGCC hexanucleotide repeats within the first intron of the
C9orf72 gene represent the predominant genetic etiology underlying amyotrophic lateral …

The misfolding, aggregation, and deposition of specific proteins is the key hallmark of most
progressive neurodegenerative disorders such as Alzheimer's disease, Parkinson's disease …

Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disorder
characterized by the loss of upper and lower motor neurons. In general, patients succumb to …

Transport from and into the nucleus is essential to all eukaryotic life and occurs through the
nuclear pore complex (NPC). There are a multitude of data supporting a role for nuclear …

Abstract Alpha-synuclein (α-syn) mislocalization and accumulation in intracellular inclusions
is the major pathological hallmark of degenerative synucleinopathies, including Parkinson's …

Frontotemporal dementia (FTD) encompasses a collection of clinically and pathologically
diverse neurological disorders. Clinical features of behavioural and language dysfunction …

A hexanucleotide repeat expansion mutation in the first intron of C9orf72 is the most
common known genetic cause of amyotrophic lateral sclerosis and frontotemporal dementia …