Lysosomal clearance of proteotoxic stressors through autophagy is an essential process
underlying cellular homeostasis. Its failure can lead to cell death 1, 2, by initiating apoptotic …

Hexanucleotide repeat expansions of variable size in C9orf72 are the most prevalent
genetic cause of amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) …

Nucleocytoplasmic transport is the active process of nuclear transport receptors bringing
molecules across the nuclear envelope through nuclear pores. In this work I measured the …

Amyotrophic lateral sclerosis (ALS) is a degenerative neuromuscular disease of unknown
etiology characterized by the impairment of both upper and lower motor neurons. The risk …

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease that impairs motor
neuron function, leading to severe muscular atrophy. The non-cell autonomous and …

A mutation in the C9ORF72 gene is the most common genetic cause of the devastating
disorders amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). Currently …

In patients with familial amyotrophic lateral sclerosis (ALS) who carry a mutation in the
C9ORF72 gene, dipeptide-repeat proteins accumulate in nervous system tissue. Of these …

A growing wave of evidence has placed the concept of protein homeostasis at the center of
the pathogenesis of amyotrophic lateral sclerosis (ALS). This is due primarily to the …

Neurodegenerative diseases result from a failure to maintain proteostasis, and a major
hallmark of neurodegeneration is the accumulation of aggregated protein deposits in the …

Neuronal development and memory consolidation are conserved processes that rely on
nuclear-cytoplasmic transport of signaling molecules to regulate gene activity and initiate …