Tumor vascularization occurs through several distinct biological processes, which not only
vary between tumor type and anatomic location, but also occur simultaneously within the …

Hepatocellular carcinoma (HCC) is a highly heterogeneous cancer, both at the molecular
and histological level. High-throughput sequencing and gene expression profiling have …

Pericytes are vascular mural cells embedded in the basement membrane of blood
microvessels. They extend their processes along capillaries, pre-capillary arterioles and …

The vascular network delivers oxygen (O2) and nutrients to all cells within the body. It is
therefore not surprising that O2 availability serves as a primary regulator of this complex …

Angiogenesis, the growth of blood vessels, is a fundamental biological process that controls
embryonic development and is also involved in numerous life-threatening human diseases …

Interactions between endothelial cells and mural cells (pericytes and vascular smooth
muscle cells) in the blood vessel wall have recently come into focus as central processes in …

We recently identified a histological subtype of hepatocellular carcinoma (HCC), designated
as “macrotrabecular‐massive”(MTM‐HCC) and associated with specific molecular features …

Pericytes are branched cells embedded within the basement membrane of capillaries and
post-capillary venules. They provide an incomplete investment to endothelial cells, thus …

Angiogenesis, or the formation of new blood vessels from the preexisting vasculature, is a
key component in numerous physiologic and pathologic responses and has broad impact in …

Abstract The angiopoietins Ang-1 and Ang-2 have been identified as ligands of the receptor
tyrosine kinase Tie-2 (refs.,). Paracrine Ang-1–mediated activation of Tie-2 acts as a …