Role of mitochondrial reactive oxygen species in homeostasis regulation
B Zhang, C Pan, C Feng, C Yan, Y Yu, Z Chen… - Redox …, 2022 - Taylor & Francis
Mitochondria are the main source of reactive oxygen species (ROS) in cells. Early studies
have shown that mitochondrial reactive oxygen species (mROS) are related to the …
have shown that mitochondrial reactive oxygen species (mROS) are related to the …
Mitochondria as cellular and organismal signaling hubs
Mitochondria are traditionally known as the powerhouse of the cell, but their functions
extend far beyond energy production. They are vital in cellular and organismal pathways …
extend far beyond energy production. They are vital in cellular and organismal pathways …
Cellular functions of the protein kinase ATM and their relevance to human disease
The protein kinase ataxia telangiectasia mutated (ATM) is a master regulator of double-
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
strand DNA break (DSB) signalling and stress responses. For three decades, ATM has been …
[HTML][HTML] Mitochondria as signaling organelles control mammalian stem cell fate
RP Chakrabarty, NS Chandel - Cell stem cell, 2021 - cell.com
Recent evidence supports the notion that mitochondrial metabolism is necessary for the
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …
determination of stem cell fate. Historically, mitochondrial metabolism is linked to the …
[HTML][HTML] Physiological signaling functions of reactive oxygen species in stem cells: from flies to man
SA Sinenko, TY Starkova, AA Kuzmin… - Frontiers in cell and …, 2021 - frontiersin.org
Reactive oxygen species (ROS), superoxide anion and hydrogen peroxide, are generated
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …
as byproducts of oxidative phosphorylation in the mitochondria or via cell signaling-induced …
FOXO transcription factors as mediators of stress adaptation
MJ Rodriguez-Colman, TB Dansen… - … Reviews Molecular Cell …, 2024 - nature.com
The forkhead box protein O (FOXO, consisting of FOXO1, FOXO3, FOXO4 and FOXO6)
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …
transcription factors are the mammalian orthologues of Caenorhabditis elegans DAF-16 …
[HTML][HTML] The mitochondrial basis of aging
A decline in mitochondrial quality and activity has been associated with normal aging and
correlated with the development of a wide range of age-related diseases. Here, we review …
correlated with the development of a wide range of age-related diseases. Here, we review …
Mitochondrial diseases: the contribution of organelle stress responses to pathology
A Suomalainen, BJ Battersby - Nature reviews Molecular cell biology, 2018 - nature.com
Mitochondrial diseases affect one in 2,000 individuals; they can present at any age and they
can manifest in any organ. How defects in mitochondria can cause such a diverse range of …
can manifest in any organ. How defects in mitochondria can cause such a diverse range of …
[HTML][HTML] ROS function in redox signaling and oxidative stress
M Schieber, NS Chandel - Current biology, 2014 - cell.com
Oxidative stress refers to elevated intracellular levels of reactive oxygen species (ROS) that
cause damage to lipids, proteins and DNA. Oxidative stress has been linked to a myriad of …
cause damage to lipids, proteins and DNA. Oxidative stress has been linked to a myriad of …
[HTML][HTML] NAD+ replenishment improves lifespan and healthspan in ataxia telangiectasia models via mitophagy and DNA repair
EF Fang, H Kassahun, DL Croteau… - Cell metabolism, 2016 - cell.com
Ataxia telangiectasia (AT) is a rare autosomal recessive disease characterized by
progressive neurodegeneration and cerebellar ataxia. AT is causally linked to defects in …
progressive neurodegeneration and cerebellar ataxia. AT is causally linked to defects in …