The intact heart undergoes complex and multiscale remodelling processes in response to
altered mechanical cues. Remodelling of the myocardium is regulated by a combination of …

In response to myocardial infarction (MI), the wound healing response of the left ventricle
(LV) comprises overlapping inflammatory, proliferative, and maturation phases, and the …

Abstract Calcium (Ca 2+) plays a central role in cardiomyocyte excitation-contraction
coupling. To ensure an optimal electrical impulse propagation and cardiac contraction, Ca …

In the chronic stage of myocardial infarction, a significant number of patients develop life-
threatening ventricular tachycardias (VT) due to the arrhythmogenic nature of the remodeled …

The global burden caused by cardiovascular disease is substantial, with heart disease
representing the most common cause of death around the world. There remains a need to …

Cardiac regeneration, that is, restoration of the original structure and function in a damaged
heart, differs from tissue repair, in which collagen deposition and scar formation often lead to …

Despite current optimal therapeutic regimens, approximately one in four patients diagnosed
with myocardial infarction (MI) will go on to develop congestive heart failure, and heart …

Cardiac myocyte–fibroblast electrotonic coupling is a well-established fact in vitro. Indirect
evidence of its presence in vivo exists, but few functional studies have been published. This …

Aortic valve stenosis (AVS) patients experience pathogenic valve leaflet stiffening due to
excessive extracellular matrix (ECM) remodeling. Numerous microenvironmental cues …

Myocardial infarction (MI) is a major source of morbidity and mortality worldwide, with over 7
million people suffering infarctions each year. Heart muscle damaged during MI is replaced …