Mechanical stimuli have fundamental roles in articular cartilage during health and disease.
Chondrocytes respond to the physical properties of the cartilage extracellular matrix (ECM) …

Stem cells mechanosense the stiffness of their microenvironment, which impacts
differentiation. Although tissue hydration anti-correlates with stiffness, extracellular matrix …

Matrix stiffening and external mechanical stress have been linked to disease and cancer
development in multiple tissues, including the liver, where cirrhosis (which increases …

Cells alter their mechanical properties in response to their local microenvironment; this plays
a role in determining cell function and can even influence stem cell fate. Here, we identify a …

Fibrotic disease is caused by the continuous deposition of extracellular matrix by persistently
activated fibroblasts (also known as myofibroblasts), even after the resolution of the injury …

Diarthrodial joints are essential for load bearing and locomotion. Physiologically, articular
cartilage sustains millions of cycles of mechanical loading. Chondrocytes, the cells in …

The cell nucleus encloses, organizes, and protects the genome. Chromatin maintains
nuclear mechanical stability and shape in coordination with lamins and the cytoskeleton …

The three-dimensional organization of chromatin contributes to transcriptional control, but
information about native chromatin distribution is limited. Imaging chromatin in live …

How cells respond to physical cues in order to meet and withstand the physical demands of
their immediate surroundings has been of great interest for many years, with current …

The volume of the cell nucleus varies across cell types and species and is commonly
thought to be determined by the size of the genome and degree of chromatin compaction …