Some cannabinoids activate the different isoforms of PPARs (α, β and γ), as shown through
the use of reporter gene assays, binding studies, selective antagonists and knockout …

Progesterone is commonly considered as a female reproductive hormone and is well-known
for its role in pregnancy. It is less well appreciated that progesterone and its metabolite …

High-fat diet (HFD) consumption leads to obesity and a chronic state of low-grade
inflammation, named metainflammation. Notably, metainflammation contributes to …

Neurosteroids are potent and effective neuromodulators that are synthesized from
cholesterol in the brain. These agents and their synthetic derivatives influence the function of …

By rapidly modulating neuronal excitability, neurosteroids regulate physiological processes,
such as responses to stress and development. Excessive stress affects their biosynthesis …

The existence of acylethanolamides (AEs) in the mammalian brain has been known for
decades. Among AEs, palmitoylethanolamide (PEA) is abundant in the central nervous …

Alzheimer disease (AD) is the most common form of neurodegenerative dementia. Amyloid-
β deposition, neurofibrillary tangle formation, and neuro-inflammation are the major …

The biochemical and cellular changes that occur following treatment with 1-methyl-4-phenyl-
1, 2, 3, 6-tetrahyropyridine (MPTP) are remarkably similar to that seen in idiopathic …

This review highlights early efforts to translate pre-clinical and clinical findings regarding the
role of neuroactive steroids in stress adaptation and PTSD into new therapeutics for PTSD …

Fear is an emotion that serves as a driving factor in how organisms move through the world.
In this review, we discuss the current understandings of the subjective experience of fear …