Neoadjuvant and adjuvant systemic therapies in loco-regional treatments for hepatocellular carcinoma: are we at the dawn of a new era?

R Nevola, A Delle Femine, V Rosato, LA Kondili… - Cancers, 2023 - mdpi.com
Simple Summary The treatment of hepatocellular carcinoma is burdened by an
unacceptable recurrence rate after loco-regional treatment. Unlike all other solid tumors, no …

Novel adjuvant dendritic cell therapy with transfection of heat-shock protein 70 messenger RNA for patients with hepatocellular carcinoma: a phase I/II prospective …

HM Matsui, S Hazama, M Nakajima, M Xu… - Cancer Immunology …, 2021 - Springer
Introduction A proteomic analysis of hepatocellular carcinoma (HCC) has revealed that Heat
Shock Protein 70 (HSP70) is among the cancer antigen proteins of HCC. Moreover, we …

Adoptive cell transfer therapy for hepatocellular carcinoma

R Zhang, Z Zhang, Z Liu, D Wei, X Wu, H Bian… - Frontiers of …, 2019 - Springer
Hepatocellular carcinoma (HCC) is one of the most common cancers worldwide. This
malignancy is associated with poor prognosis and high mortality. Novel approaches for …

CXCL2/10/12/14 are prognostic biomarkers and correlated with immune infiltration in hepatocellular carcinoma

T Lin, E Zhang, P Mai, Y Zhang, X Chen… - Bioscience …, 2021 - portlandpress.com
Background: CxC motif chemokine ligands (CXCLs) are critical regulators of cancer
immunity and angiogenesis, which affect disease progression and treatment responses. The …

Immunotherapy in hepatocellular carcinoma: is there a light at the end of the tunnel?

A Mahipal, SH Tella, A Kommalapati, A Lim, R Kim - Cancers, 2019 - mdpi.com
Hepatocellular carcinoma (HCC) is the most common primary liver cancer with dismal
prognosis when diagnosed at advanced stages. Surgical resection of the primary tumor or …

Impact and novel perspective of immune checkpoint inhibitors in patients with early and intermediate stage HCC

L Marzi, A Mega, S Gitto, F Pelizzaro, A Seeber… - Cancers, 2022 - mdpi.com
Simple Summary The prognostic evaluation and therapeutic management of
hepatocarcinoma (HCC) is based on the Barcelona Liver Cancer Clinic (BCLC). In the past …

Adjuvant and neoadjuvant therapies for hepatocellular carcinoma

A Vogel, RC Grant, T Meyer, G Sapisochin… - Hepatology, 2023 - journals.lww.com
Immune-oncology based regimens have shown efficacy in advanced hepatocellular
carcinoma and have been implemented as standard of care as first line therapy. Their …

Activity of IL-12/15/18 primed natural killer cells against hepatocellular carcinoma

L Zhuang, RJ Fulton, P Rettman, AE Sayan… - Hepatology …, 2019 - Springer
Background Hepatocellular carcinoma (HCC) is common, but remains difficult to treat.
Natural killer (NK) cells are cells of the innate immune system that have potent anti-cancer …

Emerging treatment modalities for systemic therapy in hepatocellular carcinoma

X Qing, W Xu, J Zong, X Du, H Peng, Y Zhang - Biomarker Research, 2021 - Springer
Hepatocellular carcinoma (HCC) has long been a major global clinical problem as one of
the most common malignant tumours with a high rate of recurrence and mortality. Although …

PD-L1 expression as a predictive biomarker for cytokine-induced killer cell immunotherapy in patients with hepatocellular carcinoma

CL Chen, QZ Pan, JJ Zhao, Y Wang, YQ Li… - …, 2016 - Taylor & Francis
Cytokine-induced killer (CIK) cell immunotherapy represents an effective treatment strategy
for treating hepatocellular carcinoma (HCC). However, the therapeutic benefits of CIK cell …