A mathematical model that integrates cardiac electrophysiology, mechanics, and fluid dynamics: Application to the human left heart

M Bucelli, A Zingaro, PC Africa… - … journal for numerical …, 2023 - Wiley Online Library
We propose a mathematical and numerical model for the simulation of the heart function that
couples cardiac electrophysiology, active and passive mechanics and hemodynamics, and …

[HTML][HTML] Electro-mechanical whole-heart digital twins: a fully coupled multi-physics approach

T Gerach, S Schuler, J Fröhlich, L Lindner… - Mathematics, 2021 - mdpi.com
Mathematical models of the human heart are evolving to become a cornerstone of precision
medicine and support clinical decision making by providing a powerful tool to understand …

Polygonal surface processing and mesh generation tools for the numerical simulation of the cardiac function

M Fedele, A Quarteroni - International Journal for Numerical …, 2021 - Wiley Online Library
In order to simulate the cardiac function for a patient‐specific geometry, the generation of the
computational mesh is crucially important. In practice, the input is typically a set of …

[HTML][HTML] Simulating ventricular systolic motion in a four-chamber heart model with spatially varying robin boundary conditions to model the effect of the pericardium

M Strocchi, MAF Gsell, CM Augustin, O Razeghi… - Journal of …, 2020 - Elsevier
The pericardium affects cardiac motion by limiting epicardial displacement normal to the
surface. In computational studies, it is important for the model to replicate realistic motion, as …

A geometric multiscale model for the numerical simulation of blood flow in the human left heart

A Zingaro, I Fumagalli, L Dede, M Fedele… - arXiv preprint arXiv …, 2021 - arxiv.org
We present a new computational model for the numerical simulation of blood flow in the
human left heart. To this aim, we use the Navier-Stokes equations in an Arbitrary Lagrangian …

[HTML][HTML] An electromechanics-driven fluid dynamics model for the simulation of the whole human heart

A Zingaro, M Bucelli, R Piersanti, F Regazzoni… - Journal of …, 2024 - Elsevier
We introduce a multiphysics and geometric multiscale computational model, suitable to
describe the hemodynamics of the whole human heart, driven by a four-chamber …

Data integration for the numerical simulation of cardiac electrophysiology

S Pagani, L Dede', A Manzoni… - Pacing and Clinical …, 2021 - Wiley Online Library
The increasing availability of extensive and accurate clinical data is rapidly shaping
cardiovascular care by improving the understanding of physiological and pathological …

[HTML][HTML] Automating image-based mesh generation and manipulation tasks in cardiac modeling workflows using meshtool

A Neic, MAF Gsell, E Karabelas, AJ Prassl, G Plank - SoftwareX, 2020 - Elsevier
Advanced cardiac modeling studies rely on the ability to generate and functionalize
personalized in silico models from tomographic multi-label image stacks. Eventually, this is …

[HTML][HTML] A computationally efficient physiologically comprehensive 3D–0D closed-loop model of the heart and circulation

CM Augustin, MAF Gsell, E Karabelas… - Computer methods in …, 2021 - Elsevier
Computer models of cardiac electro-mechanics (EM) show promise as an effective means
for the quantitative analysis of clinical data and, potentially, for predicting therapeutic …

Recapitulating cardiac structure and function in vitro from simple to complex engineering

ARMP Santos, Y Jang, I Son, J Kim, Y Park - Micromachines, 2021 - mdpi.com
Cardiac tissue engineering aims to generate in vivo-like functional tissue for the study of
cardiac development, homeostasis, and regeneration. Since the heart is composed of …