Candidate drugs that can be metabolically transformed into reactive electrophilic products,
such as epoxides, quinones, and nitroso compounds, are of special concern because …

Increasing evidence suggests that alpha-synuclein (α-syn) oligomers are obligate
intermediates in the pathway involved in α-syn fibrillization and Lewy body (LB) formation …

Although it has been nearly two and half decades since the discovery of alpha-synuclein
(aSyn) as the major component of Lewy bodies (LBs), our understanding of the involvement …

Proteins are continuously exposed to reactive chemical species owing to physiological and
chemical stresses, resulting in various chemical modifications such as oxidation, nitration …

One of the major scientific questions in Parkinson's disease (PD) research is what makes the
dopaminergic neurons in the substantia nigra pars compacta vulnerable. Since the early …

This review explores the interaction between nitric oxide-derived reactive species and
unsaturated fatty acids, leading to the formation of electrophilic nitroalkenes, named nitro …

Proteostasis is defined as the integrated mechanisms within cells that control protein
biogenesis, folding, trafficking and degradation. 1 The integrity of the proteome is essential …

Parkinson's disease (PD) is the second most common neurodegenerative disease, affecting
six million people worldwide. PD results from the specific loss of substantia nigra …

A neuropathologic hallmark of Parkinson's disease is the presence in post-mortem brains of
Lewy body inclusions enriched with fibrillar forms of the presynaptic protein α-synuclein (α …

The present disclosure is based, in part, on the discovery of antibodies that selectively
targets human α-synuclein aggregates such as oligomers/protofibrils, such as BAN0805 …