Endothelial cells (ECs) are a key cellular component of the vascular system as they form the
inner lining of the blood vessels. Recent findings highlight that ECs express extensive …

The pancreatic islets are one of the most vascularized organs of the body. This likely reflects
the requirements of the organ for a rich supply of nutrients and oxygen to the tissue, as well …

The growth of both tumors and nonneoplastic tissues may be influenced by signals from the
vascular endothelium. In the present investigation we show that purified proliferating …

Aims/hypothesis The proximity of endothelial cells and beta cells in islets by necessity
means that they are exposed to each other's products. Whereas islet endothelial cells …

The intra-islet microvasculature is a critical interface between the blood and islet endocrine
cells governing a number of cellular and pathophysiological processes associated with the …

OBJECTIVE Loss of thrombospondin (TSP)-1 in pancreatic islets has been shown to cause
islet hyperplasia. This study tested the hypothesis that endothelial-derived TSP-1 is …

The microvasculature is a key interface between blood and tissues and participates in
numerous pathophysiological processes. The heterogeneity of microvascular endothelial …

The revascularization and the structural changes resulting from interactions between the
graft and the host were investigated in transplanted pancreatic islets under the kidney …

OBJECTIVE—Insufficient development of a new intra-islet capillary network after
transplantation may be one contributing factor to the failure of islet grafts in clinical …

Aims/hypothesis The blood perfusion of individual pancreatic islets is highly variable, with a
subgroup of islets having high perfusion and blood vessels responsive to further blood flow …