miRNAs orchestration of cardiovascular diseases–Particular emphasis on diagnosis, and progression

EGE Elsakka, AI Abulsoud, HA El-Mahdy… - … -Research and Practice, 2023 - Elsevier
MicroRNAs (miRNAs; miRs) are small non-coding ribonucleic acids sequences vital in
regulating gene expression. They are significant in many biological and pathological …

Imaging the heart in pulmonary hypertension: an update

E Grünig, AJ Peacock - European Respiratory Review, 2015 - Eur Respiratory Soc
Noninvasive imaging of the heart plays an important role in the diagnosis and management
of pulmonary hypertension (PH), and several well-established techniques are available for …

MicroRNAs in pulmonary hypertension, from pathogenesis to diagnosis and treatment

J Xu, J Linneman, Y Zhong, H Yin, Q Xia, K Kang… - Biomolecules, 2022 - mdpi.com
Pulmonary hypertension (PH) is a fatal and untreatable disease, ultimately leading to right
heart failure and eventually death. microRNAs are small, non-coding endogenous RNA …

LncRNA CASC2 inhibits hypoxia-induced pulmonary artery smooth muscle cell proliferation and migration by regulating the miR-222/ING5 axis

Y Han, Y Liu, C Yang, C Gao, X Guo… - Cellular & molecular …, 2020 - Springer
Background Pulmonary arterial hypertension (PAH) is often characterized by cell
proliferation and migration of pulmonary arterial smooth muscle cells (PASMCs). LncRNA …

Anti-inflammatory and immunosuppressive agents in PAH

J Meloche, S Renard, S Provencher… - … of Pulmonary Hypertension, 2013 - Springer
Pulmonary arterial hypertension (PAH) pathobiology involves a remodeling process in distal
pulmonary arteries, as well as vasoconstriction and in situ thrombosis, leading to enhanced …

Biomarkers for pediatric pulmonary arterial hypertension–a call to collaborate

KL Colvin, MJ Dufva, RP Delaney, DD Ivy… - Frontiers in …, 2014 - frontiersin.org
Therapeutic approaches in pediatric pulmonary arterial hypertension (PAH) are based
primarily on clinician experience, in contrast to the evidence-based approach in adults with …

miRNAs in PAH: biomarker, therapeutic target or both?

J Meloche, A Pflieger, M Vaillancourt, C Graydon… - Drug discovery today, 2014 - Elsevier
Highlights•miRNA expression is generally tissue specific and regulated in time.•miRNAs
could be used as biomarkers and new potential therapies.•miRNAs function as upstream …

Biomarkers for pediatric pulmonary arterial hypertension: challenges and recommendations

O Lohani, KL Colvin, ME Yeager - Paediatric Respiratory Reviews, 2015 - Elsevier
Pediatric pulmonary arterial hypertension (PAH) is an uncommon disease that can occur in
neonates, infants, and children, and is associated with high morbidity and mortality. Despite …

Critical effects of epigenetic regulation in pulmonary arterial hypertension

D Chen, W Gao, S Wang, B Ni, Y Gao - Cellular and Molecular Life …, 2017 - Springer
Pulmonary arterial hypertension (PAH) is characterized by persistent pulmonary
vasoconstriction and pulmonary vascular remodeling. The pathogenic mechanisms of PAH …

[PDF][PDF] Diagnosis and management of hypertension understanding imperative role of various biomarkers

SP Shah, KK Sah, A Bansal, A Sharma… - Journal of medical …, 2023 - jmpas.com
As hypertension, almost 90% of cases of hypertension with an unknown origin called as
essential hypertension, continues to be one of the most important risk factors for various fatal …