Understanding microRNA-mediated gene regulatory networks through mathematical modelling

X Lai, O Wolkenhauer, J Vera - Nucleic acids research, 2016 - academic.oup.com
The discovery of microRNAs (miRNAs) has added a new player to the regulation of gene
expression. With the increasing number of molecular species involved in gene regulatory …

Highlights of recent developments and trends in cancer nanotechnology research—View from NCI Alliance for Nanotechnology in Cancer

LC Hull, D Farrell, P Grodzinski - Biotechnology advances, 2014 - Elsevier
Although the incidence of cancer and cancer related deaths in the United States has
decreased over the past two decades due to improvements in early detection and treatment …

MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response

A Iyer, E Zurolo, A Prabowo, K Fluiter, WGM Spliet… - 2012 - journals.plos.org
Increasing evidence supports the involvement of microRNAs (miRNA) in the regulation of
inflammation in human neurological disorders. In the present study we investigated the role …

Scanometric microRNA array profiling of prostate cancer markers using spherical nucleic acid–gold nanoparticle conjugates

AH Alhasan, DY Kim, WL Daniel, E Watson… - Analytical …, 2012 - ACS Publications
We report the development of a novel Scanometric MicroRNA (Scano-miR) platform for the
detection of relatively low abundance miRNAs with high specificity and reproducibility. The …

Loss of SHIP-1 protein expression in high-risk myelodysplastic syndromes is associated with miR-210 and miR-155

DW Lee, M Futami, M Carroll, Y Feng, Z Wang… - Oncogene, 2012 - nature.com
The myelodysplastic syndromes (MDSs) comprise a group of disorders characterized by
multistage progression from cytopenias to acute myeloid leukemia (AML). They display …

MicroRNA-Regulated Networks: The Perfect Storm for Classical Molecular Biology, the Ideal Scenario for Systems Biology

J Vera, X Lai, U Schmitz, O Wolkenhauer - MicroRNA Cancer Regulation …, 2013 - Springer
MicroRNAs (miRNAs) are involved in many regulatory pathways some of which are complex
networks enriched in regulatory motifs like positive or negative feedback loops or coherent …

Regulation of coagulation factor XI expression by microRNAs in the human liver

S Salloum-Asfar, R Teruel-Montoya, AB Arroyo… - PloS one, 2014 - journals.plos.org
High levels of factor XI (FXI) increase the risk of thromboembolic disease. However, the
genetic and environmental factors regulating FXI expression are still largely unknown. The …

MicroRNA expression profiles in metastatic and non-metastatic giant cell tumor of bone

N Mosakhani, L Pazzaglia, MS Benassi, I Borze… - 2013 - digitum.um.es
Giant cell tumor of bone (GCTB) is a skeletal neoplasm, a locally aggressive tumor that
occasionally metastasizes to the lungs. To identify novel biomarkers associated with GCTB …

The RNA world in the 21st century—a systems approach to finding non-coding keys to clinical questions

U Schmitz, H Naderi-Meshkin, SK Gupta… - Briefings in …, 2016 - academic.oup.com
There was evidence that RNAs are a functionally rich class of molecules not only since the
arrival of the next-generation sequencing technology. Non-coding RNAs (ncRNA) could be …

An evolutionarily biased distribution of miRNA sites toward regulatory genes with high promoter-driven intrinsic transcriptional noise

H Zare, A Khodursky, V Sartorelli - BMC evolutionary biology, 2014 - Springer
Background miRNAs are a major class of regulators of gene expression in metazoans. By
targeting cognate mRNAs, miRNAs are involved in regulating most, if not all, biological …