The ubiquitin-proteasomal system is an essential element of the protein quality control
machinery in cells. The central part of this system is the 20S proteasome. The proteasome is …

Small molecule inhibitors are prime reagents for studies in microtubule cytoskeleton
research, being applicable across a range of biological models and not requiring genetic …

First line therapy for non–small cell lung carcinoma (NSCLC) commonly includes
combination therapy with a tubulin-binding agent (TBA) and a DNA-damaging agent. TBAs …

Combining chemotherapeutics is a promising method of improving cancer treatment;
however, the clinical success of combination therapy is limited by the distinct …

Gastric cancer (GC) is known as a deadly malignancy all over the world, yet none of the
current therapeutic regimens have achieved efficacy. this current study has aimed to …

Chemotherapy for cancer treatment is limited by the excessive toxicity to normal tissues. The
design of chemodrug‐loaded nanoformulations provides a unique approach to improve the …

In this study, we report the efficacy of RGD (arginine-glycine-aspartic acid) peptide-modified
polylactic acid-co-glycolic acid (PLGA)-Chitosan nanoparticle (CSNP) for integrin αvβ3 …

Caspase-8 is a key effector of death-receptor-triggered apoptosis. In a previous study, we
demonstrated, however, that caspase-8 can also be activated in a death receptor …

Cajanol (5-hydroxy-3-(4-hydroxy-2-methoxyphenyl)-7-methoxychroman-4-one) is an
isoflavanone from Pigeonpea [Cajanus cajan (L.) Millsp.] roots. As the most effective …

Sirolimus and paclitaxel eluted from stents inhibit cell proliferation and other cellular
processes by dramatically different mechanisms. In this study, the effects of sirolimus and …